Letters |
March 2012 EPCA-2 marker for prostate cancerEddy S. Leman, PhD, et al., published in 2007 a study about what they believed to be a highly promising new prostate cancer biomarker, early prostate cancer antigen 2, or EPCA-2 (EPCA-2: a highly specific serum marker for prostate cancer. Urology. 2007;69:714–720). In my November 2009 letter to CAP TODAY, I criticized this biomarker, saying that close examination of the study revealed methodological and interpretative shortcomings. One of the original authors, Robert H. Getzenberg, PhD, provided a rebuttal in the same issue. Dr. Leman and Dr. Getzenberg and their coauthors have now retracted their 2007 paper (Urology. 2012;79:490), explaining that the article contains findings that may be unreliable. Eletherios P. Diamandis, MD, PhD |