Faster results, earlier treatment
July 2000
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Point-of-care assays for troponin have extended the clinical value
of this marker beyond its initial utility. "Bedside markers, especially
troponin, have enabled us to reduce the time to treatment in the 50
percent of patients who come in with ischemic heart disease who do
not have a telltale sign," says Dr. Raymond Bahr, medical director
of the Paul Dudley White Coronary Care System at St. Agnes Health
Care, Baltimore.
Bert Morton, MD, director of the clinical chemistry laboratory
at St. Agnes Health Care, has been collaborating with Dr. Bahr on
bedside troponin assays. "In mid-1999, we elected to study how the
use of bedside cardiac markers would affect patient care, particularly
in the ED," Dr. Morton says. Over the ensuing five to six months
they used simultaneously a Spectral Diagnostics point-of-care device
for troponin I, myoglobin, and CK-MB and routine laboratory assays
for the same markers, and they compared them.
"The data is very impressive from the standpoint of being able
to identify very rapidly those patients who have myocardial injury,
or frank MI, and in some instances those who had suspected myocardial
injury," Dr. Morton told CAP TODAY. "Suspected myocardial injury"
refers to clinical evidence of ischemia, such as chest pain, but
not elevated CK-MB and not clearcut ECG changes. "These are the
patients we are really looking for," Dr. Morton says. "They probably
have unstable angina or non-Q-wave MI and from all other studies
will benefit from further followup and intervention."
In this and other clinical trials, handheld troponin devices have
been proven reliably to detect acute coronary syndromes (ACS), being
positive in more than one-third of patients eventually found to
have unstable angina or non-Q-wave MI. Says Dr. Bahr, "It used to
be when you drew blood and did markers, results would come back
two hours later, when the ED physician and nurse were not present
to make a decision. They were off stopping a GI bleed. So the advantage
of bedside markers is that they have been proven to be accurate
and to correlate well with serum markers, and we can get results
in 10 to 15 minutes at the bedside with the caregivers still there.
Now if we get a positive marker," Dr. Bahr continues, "especially
troponin, that makes that patient a high-risk patient. That patient
can be given low-molecular-weight heparin and platelet inhibitors
to cool off the event. And we can do cardiac catheterization a short
time later."
Dr. Robert Christenson, director of clinical chemistry laboratories,
professor of pathology, and director of point-of-care testing at
the University of Maryland School of Medicine, concedes it may be
"trite," but one study suggested that "time is muscle" for interventions
in ACS patients just as for thrombolytic therapy. "If these data
hold up and an intervention can be started earlier in the ED, then
it should be," Dr. Christenson says. "That will be a key driver
for point-of-care testing for ACS patients." He adds, "It would
be untenable to not obtain ECG data on presentation, and the same
would be true for troponin." Early and other studies, he says, may
provide evidence that will drive the need for the troponin result
immediately in the ED.
Dr. Christenson used a troponin T rapid assay, on which he has
published papers on performance characteristics of the first- and
second-generation assays. Director of POC testing at his hospital,
he says there was no problem with his oversight of cardiac POC testing.
"Clinicians are aware of regulatory issues on POC testing, so
they are glad to have the help," Dr. Christenson has found. "They
want a reliable, fast result in their hands. The turf war over who
controls testing is not an issue. What is an issue," he says, "is
if you are viewed as an obstructionist, if you give the impression
that the service is not offered because of the extra bother involved
or if you question whether clinicians really need an immediate result."
Now that earlier test results are possible, earlier therapy is
being evaluated. In an ongoing study, investigators are looking
at whether treatment with a Gp IIb/IIIa inhibitor in the ED is better
than waiting until the patient is moved to the cardiology unit,
a difference of one hour versus three to five hours.
William Check, PhD
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