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cfDNA reference standard for EGFR mutations, 3/18

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March 2018—Horizon Discovery launched its EGFR Multiplex cfDNA Reference Standard. The cell line-derived EGFR multiplex cell-free DNA reference standard allows laboratories and assay developers to optimize, validate, and routinely monitor performance of polymerase chain reaction–based tests, next-generation sequencing, and other novel assays designed to detect EGFR mutations from cfDNA.

The reference standard covers 10 of the most clinically relevant mutations that predict responsiveness to EGFR tyrosine kinase inhibitors, including T790M, L858R, C797S, and E746-A750del. These variants have been carefully selected to represent a mix of different mutation types, such as single nucleotide polymorphisms and indels. It is supplied in a DNA fragment range of 160 base pairs, which is comparable to the DNA size found in real samples, and comes in a set of four vials, with allelic frequencies from five percent to 0.1 percent, along with a matched EGFR wild type, enabling determination of assay specificity, sensitivity, and limit of detection.

Horizon Discovery, 314-449-9251

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