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| Name of instrument/First year sold/Where designed | ARCHITECT i2000/1998, i2000SR/2003, i4000SR/2007/U.S. |
| Country where manufactured/Where reagents manufactured | U.S., Japan/U.S., Europe |
| No. of units in clinical use in U.S./Outside U.S. | 498/6,527 |
| Operational type/Model type/Sample handling system | batch, random access, continuous random access/floor-standing/track and LAS |
| Dimensions in inches (H × W × D)/Instrument footprint in sq. feet | 48 × 61 × 49/20.3, i2000, 48 × 68 × 44/22.7 per module |
| Tests available on instrument in U.S. | HIV Ag/Ab Combo, vitamin D, vitamin B12, folate, HE-4, CA 125, CA 15-3, CA 19-9 XR, CEA, Free PSA, total PSA, BNP, CK-MB, myoglobin, troponin-I, DHEA-S, estradiol, FSH, hCG (total B-hCG), LH, progesterone, prolactin, SHBG, anti-HAV IgM, anti-HBc, anti-HBc IgM, anti-HBs, anti-HCV, HBsAg, HBsAg confirmatory, C-peptide, cortisol, ferritin, homocysteine, insulin, intact PTH, digoxin, phenobarbital, phenytoin, theophylline, many others |
| Tests not available in U.S. but submitted for clearance | HAVAB, testosterone |
| Tests not available in U.S. but available in other countries | AFP, anti-HAV IgG, NGAL, proGRP, MPO, SCC, anti-HAV IgG, anti-HBe, HBeAg, CMV IgG, CMV IgG avidity, others |
| Tests in development | anti-HAV IgG, methotrexate, Tg |
| Tests not available on other manufacturers’ analyzers | — |
| Fully automated microplate system | no |
| Number of each analyte performed in separate disposable unit | — |
| Number of wells in microplate | — |
| Methods supported/Separation methods | Chemiflex (enhanced chemiluminescence) with 5 flexible protocols/magnetic microparticle |
| Number of different measured assays onboard simultaneously | 25 |
| Number of different assays programmed, calibrated at once | 25 |
| Number of user-definable (open) channels | — |
| Number of different analytes for which system accommodates reagent containers onboard at once/Tests per container set | 25/100-test and 500-test per kit |
| Shortest/Median onboard reagent stability/Refrigerated onboard | —/30 days tracked in hours/yes |
| Multiple reagent configurations supported | yes |
| Reagent container placed directly on system for use | yes |
| Reagents bar coded/Information in bar code | yes/assay No., reagent serial No., lot No., tests per kit, exp. date, onboard stability time, master calibration curve |
| Same capabilities when 3rd-party reagents used/Susceptibility to carryover | no/<0.1ppm |
| Walkaway capacity in minutes/Specimens/Tests-assays | 300/135/12,500 |
| System is open (home-brew methods can be used)/Liquid or dry system | no/liquid |
| Uses disposable cuvettes/Maximum number stored | yes/1,200 |
| Uses washable cuvettes/Replacement frequency | no/— |
| Minimum specimen volume required | 50 µL |
| Minimum sample vol. aspirated precisely at once/Minimum dead volume | 150 µL/50 µL for all tube types |
| Supplied with UPS (backup power)/Requires floor drain | yes/no |
| Requires dedicated water system/Water consumption | no/— |
| Noise generated | 48–70 decibels |
| Has dedicated pediatric sample cup/Dead volume | no/— |
| Primary tube sampling/Tube sizes/Pierces caps on primary tubes | yes/5, 7, 10 mL/no |
| Sample bar-code reading capability/Autodiscrimination | yes (2 of 5 interleaved, Codabar, codes 39 and 128)/yes |
| Bar-code placement per CLSI standard Auto2A | yes |
| Onboard test auto inventory (determines volume in container) | yes |
| Measures No. of tests remaining/Short sample detection | yes/yes |
| Auto detection of adequate reagent or specimen | yes |
| Clot detection/Reflex testing capability | yes/yes |
| Hemolysis detection-quantitation/Turbidity detection-quantitation | no/no |
| Dilution of patient samples onboard/Automatic rerun capability | yes/yes |
| Sample volume can be increased to rerun out-of-linear range high results/ Increased to rerun out-of-linear range low results | no/no |
| Time between initial result and reaspiration of sample for rerun | <20 seconds |
| Autocalibration or autocalibration alert | yes |
| Number of calibrators required for each analyte | 2–6 point curve |
| Calibrants can be stored onboard/Average calibration frequency | no/calibration required with new lot |
| Multipoint calib. supported/Multiple calibs. stored for same assay | yes/yes (up to 4 curves/analyte) |
| How often QC required | 3 levels every 24 hours for quantitative, 2 levels for qualitative |
| Onboard real-time QC/Support multiple QC lot Nos. per analyte | yes/yes |
| Automatic shutdown/Startup is programmable/Startup time | —/no/10 minutes |
| Stat time to completion of β-hCG test | 15.6 minutes |
| Time delay from ordering stat test to aspiration of sample | <20 seconds |
| Throughput per hour for three analytes on each specimen, in No. of specimens/No. of tests (cycle time) | 67/200 tests per hour |
| Can auto transfer QC results to LIS/Onboard capability to review QC | yes/yes |
| Data-management capability/Instrument vendor supplies LIS interface | onboard/no |
| LIS interfaces up and running in active user sites | all major LIS vendors |
| LIS interface operates simultaneously w/running assays | yes |
| Bidirectional interface capability | yes (broadcast download and host query) |
| Interface available (or will be) to auto specimen handling system | yes |
| Modem servicing/Can diagnose own malfunctions/ Determine malfunctioning component | yes/yes/yes |
| Can order (via modem) malfunctioning part(s) w/o operator | yes, AbbottLink |
| On-site response time of service engineer | per negotiated contract |
| Mean time between failures/To repair failures | 13 weeks/per negotiated contract |
| Avg. time to complete maintenance by lab personnel | daily: 16 minutes; weekly: <10 minutes; monthly: none (for both manual and auto procedures) |
| Onboard maintenance records/Maintenance training demo module | yes/yes |
| List price/Targeted bed size or daily volume | $169,500/>200 immunoassay tests per day |
| Annual service contract cost (24 hours/7 days) | flexible options available |
| Training provided w/purchase/Advanced operator training | yes/yes |
| Distinguishing features (supplied by vendor) | Chemiflex technology delivers excellent sensitivities and extended linearities, RSH allows priority and routine samples to be processed simultaneously without compromising stats; refer to operations manual for operational precautions, limitations, and hazards; class 1 laser product |
| Tabulation does not represent an endorsement by the College of American Pathologists. |
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