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| Name of instrument/First year sold/Where designed | ARCHITECT i1000SR/2008/U.S. |
| Country where manufactured/Where reagents manufactured | Singapore/U.S., Europe |
| No. of units in clinical use in U.S./Outside U.S. | 973/4,412 |
| Operational type/Model type/Sample handling system | continuous random access/floor-standing/robotic sample handler allows batch, random access, continuous access and reagent loading and unloading |
| Dimensions in inches (H × W × D)/Instrument footprint in sq. feet | 49 × 59 × 30/12.3 |
| Tests available on instrument in U.S. | HIV Ag/Ab Combo, vitamin D, vitamin B12, folate, testosterone, HbA1c, HE-4, CA 125, CA 15-3, CA 19-9 XR, CEA, free PSA, Total PSA, BNP, CK-MB, troponin I, DHEA-S, estradiol, FSH, hCG (Total B-hCG), LH, progesterone, prolactin, SHBG, anti-HAV IgM, Anti-HBc IgM, anti-HCV, anti-CCP, C-peptide, cortisol, ferritin, homocysteine, insulin, intact PTH, digoxin, phenobarbital, phenytoin, theophylline, valproic acid, vancomycin, anti-Tg, anti-TPO, many others |
| Tests not available in U.S. but submitted for clearance | — |
| Tests not available in U.S. but available in other countries | AFP, ProGRP, NGAL, high-sensitivity troponin I, galectin-3, others |
| Tests in development | methotrexate, Tg |
| Tests not available on other manufacturers’ analyzers | — |
| Fully automated microplate system | — |
| Number of each analyte performed in separate disposable unit | — |
| Number of wells in microplate | — |
| Methods supported/Separation methods | chemiluminescence/magnetic particle |
| Number of different measured assays onboard simultaneously | 25 |
| Number of different assays programmed, calibrated at once | 61 |
| Number of user-definable (open) channels | none |
| Number of different analytes for which system accommodates reagent containers onboard at once/Tests per container set | 25/100 |
| Shortest/Median onboard reagent stability/Refrigerated onboard | 14 days (vitamin D)/30 days tracked in hours/yes |
| Multiple reagent configurations supported | yes |
| Reagent container placed directly on system for use | yes |
| Reagents bar coded/Information in bar code | yes/assay number, reagent serial number, lot number, test per kit, expiration onboard stability time, others |
| Same capabilities when 3rd-party reagents used/Susceptibility to carryover | no/<0.1 ppm |
| Walkaway capacity in minutes/Specimens/Tests-assays | 180/65/25 |
| System is open (home-brew methods can be used)/Liquid or dry system | no/liquid |
| Uses disposable cuvettes/Maximum number stored | yes/360 |
| Uses washable cuvettes/Replacement frequency | no/— |
| Minimum specimen volume required | varies based on assay |
| Minimum sample vol. aspirated precisely at once/Minimum dead volume | 10 µL/50 µL |
| Supplied with UPS (backup power)/Requires floor drain | yes/no |
| Requires dedicated water system/Water consumption | no/— |
| Noise generated | 58 decibels during normal operation, 62 decibels maximum |
| Has dedicated pediatric sample cup/Dead volume | no/— |
| Primary tube sampling/Tube sizes/Pierces caps on primary tubes | yes/5-, 7-,10-mL tubes and sample cups/no |
| Sample bar-code reading capability/Autodiscrimination | yes (2 of 5 interleaved, Codabar, codes 39 and 128)/yes |
| Bar-code placement per CLSI standard Auto2A | yes |
| Onboard test auto inventory (determines volume in container) | yes |
| Measures No. of tests remaining/Short sample detection | yes/yes |
| Auto detection of adequate reagent or specimen | yes |
| Clot detection/Reflex testing capability | yes/yes |
| Hemolysis detection-quantitation/Turbidity detection-quantitation | no/no |
| Dilution of patient samples onboard/Automatic rerun capability | yes/yes |
| Sample volume can be increased to rerun out-of-linear range high results/ Increased to rerun out-of-linear range low results | no/no |
| Time between initial result and reaspiration of sample for rerun | — |
| Autocalibration or autocalibration alert | yes |
| Number of calibrators required for each analyte | 2–6, assay dependent |
| Calibrants can be stored onboard/Average calibration frequency | no/calibration required with new lot |
| Multipoint calib. supported/Multiple calibs. stored for same assay | yes/yes (up to 4 curves/analyte) |
| How often QC required | every 24 hours or per lab specific procedure |
| Onboard real-time QC/Support multiple QC lot Nos. per analyte | yes/yes |
| Automatic shutdown/Startup is programmable/Startup time | no/no/6.5 minutes |
| Stat time to completion of β-hCG test | 18 minutes |
| Time delay from ordering stat test to aspiration of sample | — |
| Throughput per hour for three analytes on each specimen, in No. of specimens/No. of tests (cycle time) | up to 33 samples/100 tests per hour |
| Can auto transfer QC results to LIS/Onboard capability to review QC | yes/yes |
| Data-management capability/Instrument vendor supplies LIS interface | onboard/no |
| LIS interfaces up and running in active user sites | all major LIS vendors |
| LIS interface operates simultaneously w/running assays | yes |
| Bidirectional interface capability | yes (broadcast download and host query) |
| Interface available (or will be) to auto specimen handling system | yes |
| Modem servicing/Can diagnose own malfunctions/ Determine malfunctioning component | yes/yes/yes |
| Can order (via modem) malfunctioning part(s) w/o operator | yes |
| On-site response time of service engineer | — |
| Mean time between failures/To repair failures | 26 weeks/— |
| Avg. time to complete maintenance by lab personnel | daily: 10 minutes; weekly: 17 minutes; monthly: 90 minutes |
| Onboard maintenance records/Maintenance training demo module | yes/yes |
| List price/Targeted bed size or daily volume | $125,000/40–250 tests per day |
| Annual service contract cost (24 hours/7 days) | — |
| Training provided w/purchase/Advanced operator training | yes/yes |
| Distinguishing features (supplied by vendor) | streamlined workload management; continuous access to reagents, samples, and supplies; 65-sample load capacity; 13 universal bays, seven customizable priority bays; refrigerated reagent carousel with 25 × 100 test kit sizes; reagents stable onboard up to 30 days; priority tests; 18-minute turnaround time on stat assays |
| Tabulation does not represent an endorsement by the College of American Pathologists. |
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