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Siemens Healthcare Diagnostics, ADVIA 2400 (Chemistry 2014)

Siemens Healthcare Diagnostics, ADVIA 2400 (Chemistry 2014)

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Chemistry analyzer for high-volume laboratory
Siemens Healthcare Diagnostics Inc.
Colleen Wagener
1717 Deerfield Rd.
Deerfield, IL 60015

Name of instrument/First year sold in U.S. ADVIA 2400 Clinical Chemistry System/2003
List price/Total No. sold in 2013 $305,000/>150
Number of units in clinical use in U.S./Outside U.S. >50/>700
Where designed/Manufactured/Where reagents manufactured Japan/Japan/UK, U.S., Canada
Operational type/Reagent type continuous random access/open reagent system
Sample handling system/Model type ring, point-in-space for automation option/floor-standing
Dimensions in inches (H x W x D)/Footprint in square feet 53 × 67 × 34/16
Number of tests for which analyzer has FDA-cleared applications >116
Tests released for clinical use in last 12 months albumin (BCP), lipoprotein (a), concentrated triglycerides reagent, (U.S. decision on fructosamine and myoglobin)
Tests cleared but not released for clinical use (U.S. decision on fructosamine and myoglobin)
Tests not available in U.S. but submitted for 510(k) clearance
Tests not available in U.S. but available in other countries ALP(DEA)
Research-use-only assays
Tests in development
Methodologies supported/immunoassay methodologies photometry, potentiometry, turbidimetric, EMIT technology/—
Number of direct ion-selective electrode channels 3
Number of different measured assays onboard simultaneously 46 colormetric, 3 ISE
Number of different assays programmed and calibrated at once 200
Number of user-definable (open) channels/Number active simultaneously 50/50
Number of different analytes for which system accommodates reagent containers onboard at once/Tests per container set 49/75–3,060
Shortest/Median onboard reagent stability/Refrigerated onboard 168 hours/30 days/yes
Multiple reagent configurations supported yes
Reagent container placed directly on system for use yes
Instrument has same capabilities when third-party reagents used yes
Walkaway capacity in minutes/Specimens/Tests or assays 32,000 photometric
Uses disposable cuvettes/Maximum number stored no/—
Uses washable cuvettes/Replacement frequency yes/every 4 months
Minimum sample volume aspirated precisely at one time 2 µL of diluted specimen
Supplied with UPS (backup power)/Requires floor drain yes/yes (or sink)
Requires dedicated water system/Water consumption per hour yes/<40 L
Noise generated in decibels <60 open cover, <45 closed cover
Dedicated pediatric sample cup/Dead volume yes/<50 µL
Primary tube sampling/Pierces caps on primary tubes yes/no
Sample bar-code reading capability/Autodiscrimination yes, on sample transport, shortly before sample is aspirated (2 of 5 interleaved, Codabar, codes 39 and 128)/yes
Reagent bar-code reading capability yes
Bar code placement per CLSI standard Auto2A yes
Onboard test auto inventory (determines volume in container) yes
Measures number of tests remaining/Short sample detection/Clot detection yes/yes/yes
Hemolysis/Turbidity detection-quantitation yes/yes
Sample volume can be reduced yes
Increased to rerun out-of-linear-range high/low results yes
Autocalibration or autocalibration alert yes
Calibrants stored onboard/Multipoint calibration supported yes/yes
Typical calib. frequency for ISE/Metabolites/Therapeutic drugs/Drugs of abuse daily/1–60 days, median 30 days/7–45 days, median 30 days/7–30 days, median 28 days
Automatic shutdown programmable/Startup programmable yes/yes
Stat time to completion of all analytes and throughput per hour for:
• Sodium, potassium, chloride, TC02 5.4 minutes/200 specimens
• Sodium, potassium, chloride, TC02, glucose, urea, creatinine 10.4 minutes/200 specimens
• Albumin, direct and total bilirubin, AST, ALT, ALP 10.2 minutes/300 specimens
Typical time delay from ordering stat test to aspiration of sample 10 seconds
How often QC required/Onboard SW capability to review QC 24 hours/yes
Onboard real-time QC/Support multiple QC lot numbers per analyte yes/yes
System can automatically transfer QC results to LIS yes
Data management capability/Instrument vendor supplies LIS interface onboard/yes (included)
Interfaces to what LISs up and running in active user sites all major LIS vendors
Bidirectional interface capability yes (broadcast download and host query)
Uses LOINC to transmit orders and results across interface yes
How labs get LOINC codes for reagent kits via software
Interface available (or will be) to automated specimen-handling system yes, ADVIA Automation Solutions, Aptio Automation
Modem servicing available/System can diagnose own malfunctions/System can determine malfunctioning component yes/yes/yes
On-site time of service engineer generally <4 hours
Mean time between failures/Mean time to repair failures
Average time to complete maintenance by lab personnel automated daily maintenance
Onboard maintenance records/Maintenance training demo module —/yes
Training provided with instrument purchase yes
Distinguishing features (provided by vendor) high-volume 2,400-test-per-hour chemistry system designed for automation, with onboard aliquoting that allows sample tubes to quickly pass to the next analyzer for parallel test processing, and automatically processing of reruns, dilutions, and reflex testing without waiting for the sample tube to return; micro-volume technology enables extensive testing with small sample volumes, and large onboard test capacities and concentrated reagents offer long walkaway times; comprehensive menu and many open channels support clinical care
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