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| Name of instrument | Coulter LH 750 |
| First year installed in U.S./Outside U.S./No. of units sold in 2011 | 2001/2001/261 |
| No. units installed in U.S./Outside U.S./List price | >2,300/>1,900/$195,000 |
| Test menu: • Chartable (standard menu: WBC, RBC, Hb, Hct, MCV, MCH, MCHC, PLT, %&# neut, mono, lymph, eos, baso): | standard menu (left) plus: RDW, MPV, retic #&%, IRF, MRV, graded RBC morph., NRBC %&#, TNC & RBC on CSF, synovial, and serous fluids |
| • Laboratory | — |
| • Flags | user-definable age-, gender-, or location-based reference intervals; action and critical limits; user-definable RBC morphology; gradient messages (=+, ++, +++); user-selectable sensitivity for differential abnormal population suspect messages |
| FDA-cleared tests not clinically released | — |
| Tests not available but submitted for 510(k) clearance | — |
| Tests in development | — |
| Tests for research use only | MSCV, HLR %&#, PDW, PCT, WBC research population data (RPD) |
| Tests unique to analyzer | IVD: NRBC, body fluids; RUO: MSCV, WBC RPD |
| Differential method(s) used | Coulter’s 3-D VCS biophysical flow cytometry with IntelliKinetics, AccuGate, and AccuFlex technologies |
| Linearity: | |
| • WBC count/RBC count | 0–400/0–8.0 |
| • Hemoglobin/platelet | 0–25/0–3,000 |
| • MCV (fL) or Hct (%) | — |
| Precision: | |
| • WBC count/RBC count | ≤1.7 percent/≤0.8 percent |
| • Hemoglobin/platelet | ≤0.8 percent/≤3.3 percent |
| • MCV or Hct | ≤0.8 percent (MCV) |
| Accuracy of automated differential compared with manual differential (per CLSI H-20A2) | lymph% = ±3.0%, neut% = ±2.0%, mono% = ±3.0%, eos% = ±1.0%, baso% = ±1.0% |
| Interfering substances: | |
| • WBC | unusual RBC abnormalities that resist lysing, NRBC, fragmented WBC, unlysed particle >35 fL, giant PLT, PLT clumps |
| • RBC | very high WBC, high concentration large PLT, autoagglutinins |
| • MCV or Hct | MCV and Hct: very high WBC, high concentration large PLT, autoagglutinins |
| • Platelet | very small RBCs and WBC fragments may interfere |
| • Hemoglobin | very high WBC, severe lipemia, heparin, rare lyse-resistant RBCs |
| Interfering substances: Differential | high triglycerides may affect lysing |
| Maximum CBCs per hour/Maximum CBCs and differentials per hour | 110/110 |
| Minimum specimen volume open/Closed/Sample dead volume closed | 200 µL/300 µL, 550 µL with slidemaker/1.0 mL |
| Microsample capability | yes |
| Prepares microscope slides automatically or flags problems for slide prep | yes, both |
| Number of automatic slidemakers available/List price | >1,000 (U.S.)/$110,000 |
| Archives patient data/Previous patient results included with recent results | yes/yes |
| Maximum archived data accessible when system online | 20,000 samples |
| No. specimens for which numeric results saved in memory at once | 20,000 samples |
| No. specimens for which histo/cytogram results saved in memory at once | 20,000 samples |
| Performs delta checks | yes |
| Tags and holds results for followup, confirmatory testing, or rerun | yes |
| Parameters for flags for holding samples defined by user or vendor | user or vendor |
| Scattergram display: cell-specific color | yes |
| Histogram display: color with thresholds | yes |
| User interface can display choice of specimen/result information | yes |
| LIS interface formats supported | RS-232, proprietary |
| Information transferred on LIS interface | numeric and flag results, histograms and scatterplots, instrument to LIS; patient demographics, orders, LIS to instrument—broadcast |
| LOINC codes transmitted with all results | no |
| Sent in message to LIS | no |
| Listing of machine codes and corresponding LOINC for each test | no |
| Interface available or planned to automated specimen-handling system | Beckman Coulter |
| Bar-code symbologies read on specimen tube | Codabar, codes 39 and 128, Interleaved 2 of 5, NW7 |
| Accommodates bar-code placement per CLSI standard Auto2A | yes |
| Time required for maintenance by lab personnel | no routine maintenance; only as needed |
| Onboard diagnostics for troubleshooting/Limited to software problems | yes/no |
| Manufacturer can perform diagnostics via modem | yes |
| Distinguishing features (supplied by company) | extensive decision support; enumeration of NRBCs with every differential; random access; automation ready; extended linearity for WBC and PLTs; RUO: WBC RPD |
| Note: a dash in lieu of an answer means company did not answer question or question is not applicable | |
| Tabulation does not represent an endorsement by the College of American Pathologists. |
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