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Updated CLSI Supplement M100, 3/18

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March 2018—The Clinical and Laboratory Standards Institute published its annually updated antimicrobial susceptibility testing supplement, “M100: Performance Standards for Antimicrobial Susceptibility Testing, 28th ed.,” as well as its associated methodology standards, “M02: Performance Standards for Antimicrobial Disk Susceptibility Tests, 13th ed.” and “M07: Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically, 11th ed.” M100 is available packaged with either M02 or M07 or the three documents are available packaged together.

M02 covers the current recommended methods for disk susceptibility testing and criteria for quality control testing and includes the M02 Quick Guide. M07 covers reference methods for determining minimal inhibitory concentrations of aerobic bacteria by broth macrodilution, broth microdilution, and agar dilution. M100 includes annually updated tables for M02, M07, and M11.

Highlights for the 2018 editions include the addition of breakpoints for ceftazidime-avibactam and dalbavancin, expansion of the mCIM test for detection of metallo-β-lactamases, and new tables and expanded recommendations for QC of beta-lactam combination agents.

CLSI, 610-688-0100

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