Thermo Fisher Scientific’s Orbitrap Fusion Tribrid liquid chromatography-mass spectrometry (LC-MS) system combines its quadrupole, Orbitrap, and linear ion trap mass analyzers in a “Tribrid” architecture that analyzes complex biological samples.
The Orbitrap Fusion LC-MS system addresses throughput challenges through tandem mass tags, a technique that enables mass spectrometers to determine relative quantification of proteins in multiple samples simultaneously.
At the heart of the Orbitrap Fusion system is a configuration of three mass analyzers that work together: a quadrupole for precursor selection at isolation widths down to 0.4 amu, for excellent sensitivity and selectivity; an ultra-high-field Orbitrap, offering resolution in excess of 450,000 and scan rates up to 15 Hz; and an ion-routing multipole followed by dual-pressure linear ion trap, providing MSn HCD, CID, and ETD fragmentations and fast, sensitive mass analysis with scan rates of up to 20 Hz.
The Tribrid configuration allows users to quickly identify larger numbers of low-abundance proteins. Its unique architecture enables simultaneous precursor isolation, fragmentation, and data acquisition in the Orbitrap and linear ion trap mass analyzers.
Thermo Fisher Scientific, 408-965-6408