Webinars and Sponsored Roundtables — Register Now

Tuesday, April 28, 2026, 12:00 PM–1:00 PM ET
Discover how next-day comprehensive genomic profiling (CGP) is possible with the Oncomine Comprehensive Assay Plus on the Genexus System—delivering both speed and accuracy.

Webinar presenters Jane Bayani, MHSc, PhD, Assistant Professor and Co-Director, Diagnostic Development, Ontario Institute for Cancer Research, Canada, and Nicola Normanno, MD, Scientific Director, IRCCS Romagnolo Institute for the Study of Tumors, Italy, and Morten Grauslund, PhD, Molecular Biologist, Department of Pathology, Rigshospitalet/Copenhagen University Hospital, Copenhagen, Denmark.

Moderated by: Bob McGonnagle, Publisher, CAP TODAY

CAP TODAY does not endorse any of the products or services named within. The webinar is made possible by a special educational grant from Thermo Fisher Scientific. For Research Use Only. Not for use in diagnostic applications. 

Thursday, April 30, 2026, 11:00 AM–12:00 PM ET
Hear an expert discuss how Memorial Sloan Kettering Cancer Center (MSKCC) is utilizing
the oncoReveal® Nexus 21-gene panel to redefine turnaround time and actionable insights
in cancer care. Dr. Ewalt shares a perceptive look at the clinical need for rapid, front-line NGS sequencing, and how a unique, purpose built targeted NGS panel (Pillar Biosciences’ oncoReveal Nexus 21 gene Panel) was developed, validated and implemented clinically by Memorial Sloan Kettering Cancer Center (MSK-REACT) to complement their current comprehensive genomic profiling (CGP) approach.

Webinar presenter Mark Ewalt, MD, Associate Medical Director for Laboratory Operations for Diagnostic Molecular Pathology in the Molecular Diagnostics Service, Department of Pathology and Laboratory Medicine, MSKCC.

Moderated by: Bob McGonnagle, Publisher, CAP TODAY

CAP TODAY does not endorse any of the products or services named within. The webinar is made possible by a special educational grant from Pillar Biosciences.

Thursday, May 28, 2026, 1:00–2:00 PM ET
This session is designed to improve understanding and application of recent updates to synoptic pathology reporting protocols such as the latest Reporting Template for Reporting Results of Biomarker Testing of Specimens from Patients with Carcinoma of the Breast. These changes reflect evolving clinical guidelines that directly influence diagnostic accuracy and treatment selection in breast cancer care.

Webinar presenters Thaer Khoury, MD, FCAP, Chair, Pathology and Laboratory Medicine, Roswell Park Comprehensive Cancer Cente, and Colin Murphy,  CEO of mTuitive.

Moderated by: Bob McGonnagle, Publisher, CAP TODAY

Subspecialties

Interactive Product Guides

Product Spotlight

Chrono-log Corp.

Optical Aggregation Systems Models 490 4+ | 490 4+4

Company

Chrono-log Corp.

Instrument name

Optical Aggregation Systems Models 490 4+, 490 4+4

Contact

Sal Pema  

City State

Havertown, PA

Phone

610-853-1130 or 800-247-6665

Website

https://www.chronolog.com

First year sold

2017

List price/Model type

—/benchtop

Dimensions (H × W × D)/Weight/Instrument footprint

per each 4-channel module: 8.5 × 14 × 15 in./19.3 lbs./1.5 sq. ft.

No. of units in clinical use in U.S./Outside U.S.

Composition of installs: Hospital lab/Reference lab/Other

Targeted daily, monthly, annual test volume

Operational type

discrete

Country where analyzer designed/Manufactured

U.S./U.S.

Company manufactures instrument

yes (also sold via distribution partners)

FDA-approved clotting-based tests

FDA-approved chromogenic tests

FDA-approved immunologic tests

platelet agglutination with ristocetin

Other FDA-approved tests

LTA platelet aggregation, ristocetin cofactor assay

User-defined tests in clinical use

LTA platelet aggregation, ristocetin cofactor assay

Tests in development or awaiting FDA 510(k) clearance

Methodologies supported

turbidimetric for measuring platelet aggregation in PRP and ristocetin cofactor assay

Number of different measured assays onboard simultaneously

4–8

Number of different assays programmed and calib. at one time

4–8

No. of user-definable (open) channels/No. active simultaneously

4–8/4–8

Factor assays require manual manipulation or dilutions

yes (manual dilutions)

Test throughput per hour/Assay run time

6 (24–48 tests in throughput)/5 min. minimum

Design of sample-handling system

manual

Operates on whole blood or spun plasma

spun plasma

Reagent type

self-contained multiuse vials; open reagent system (liquid, lyophilized [reconstituted manually])

Reagent barcode-reading capability

no

No. of reagent containers held onboard/Reagents ready to use

—/requires operator prehandling

Reagent lot tracking/Reagent inventory/Reagents refrigerated onboard

no/no/no

Reagents, consumables loaded without interrupting testing

yes (consumables)

Instrument uses proprietary or third-party reagents

proprietary reagents

Maximum time same lot number of reagents can be used

18 months–3 years

Walkaway capability/Walkaway duration

yes/5 min. or 4–8 specimens or 4–8 tests

Min.–max. specimen volume that can be aspirated at one time

250–500 µL

Min. sample volume required for PT/PTT/Factor VIII activity

Types of disposables used

cuvettes, stir bars, pipette tips

Primary tube sampling supported/Pierces caps on primary tubes

no/no

Accommodates most standard tube sizes/Nonstandard sizes

no/no

Sample barcode-reading capability/Autodiscrimination

no/no

Auto tracks product volume/Measures number of tests remaining

no/no

Short sample detection

no

Clot detection as preanalytical variable in plasma sample

no

Auto detects adequate reagents for aspiration or analysis

no

Detection or quantitation for hemolysis, turbidity, icterus, lipemia 

no

Dilutes patient samples onboard

no

Automatic rerun capability/Auto reflex testing capability

yes/no

Lag time during which hypercoagulable sample not detected

no

User can adjust reagent volumes/Sample volumes

yes/yes

User can adjust No. of reagents/Sources of reagents

yes/yes

User can adjust incubation times/Reading times

yes/yes

Autocalibration/Calibrants stored onboard

yes/no

Multipoint calibration supported/Recommended frequency

yes/annually

• PT alone

• PT, PTT

• Fibrinogen

• Factor VIII activity assay

• D-dimer

Time delay from ordering stat to aspiration of sample

How labs get LOINC codes for results

email query

Onboard real-time QC/Onboard software capability to review QC

yes/no

Information that can be barcode-scanned on instrument

barcode scanning not offered

Compatible with laboratory automation systems

no

Data-management capability/LIS or EHR systems interfaced

onboard/none

Interface supplied by instrument vendor

no

Results transferred to LIS as soon as test time complete

no

Bidirectional interface capability

no

Remote servicing provided/UPS backup power supply

no/no

Instrument connections to transfer information

Interface standards supported

Information transferred to data-management software

Avg. time for basic user training

Approximate scheduled maintenance time

preventive maintenance and calibration by clinical engineering recommended annually

Maintenance records kept onboard

yes

Warranty with purchase/Annual service contract cost (24/7)

yes/— (cost dependent on contract)

Distinguishing features (supplied by company)

continuously monitors and regulates temperature and stirring; optical calibration can be performed by laboratory personnel using no-cost water samples; customized color-coding options

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Sysmex CN-3000
Sysmex CN-6000
Sysmex CS-2500 System
Sysmex CS-5100 System
ACL TOP 550 CTS
ACL TOP 750 Series
ACL TOP 770/770s
ACL TOP 770 LAS
ACL TOP 970 CL