CAP TODAY Pathology/Laboratory Medicine/Laboratory Management
In the October 2018 issue was a case report (page 70), “NGS in the diagnosis of RASopathies in histologically uninformative skin biopsy samples,” written by members of the Association for Molecular Pathology. Here are answers (in bold) to the three “test yourself ” questions that followed that case report.
1. Which of the following is the most commonly mutated gene in Schimmelpenning syndrome?
a) KRAS
b) HRAS
c) NRAS
d) PTCH
2. Which of the following is the most common malignant neoplasm arising within nevus sebaceus?
a) Squamous cell carcinoma
b) Trichoblastoma
c) Basal cell carcinoma
d) Keratoacanthoma
3. Which of the following sequencing methods have been used to identify the underlying nevus sebaceus mutation?
a) Sanger sequencing
b) Whole exome sequencing
c) Targeted next-generation sequencing
d) All of the above