CAP TODAY Pathology/Laboratory Medicine/Laboratory Management
February 2020—Karius announced that JAMA Oncology published a clinical study showing that the Karius test detected bloodstream infections before the onset of clinical symptoms in high-risk pediatric patients with relapsed or refractory leukemia (Goggin KP, et al. Epub ahead of print Dec. 19, 2019. doi:10.1001/jamaoncol.2019.4120). The study was performed by researchers at St. Jude Children’s Research Hospital.
Of the 47 pediatric patients enrolled in the study, 12 patients developed a total of 19 bloodstream infections, and samples for evaluation of predictive diagnosis were available for 16 episodes. The Karius test detected a bloodstream infection in 75 percent of cases (12/16) as early as three days before patients became symptomatic.
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