Webinars and Sponsored Roundtables — Register Now
Tuesday, June 9, 2026, 1:00–2:00 PM ET
In this webinar, we will examine how immune recognition after allogeneic HCT can influence leukemia relapse and disease progression. The session will highlight the clinical relevance of HLA loss of heterozygosity (LOH), approaches used for its detection, and how LOH findings may support transplant strategies, including considerations for donor selection in subsequent transplantation.
Webinar presenter Alberto Cardoso Martins Lima, PhD, Clinical consulting scientist in histocompatibility,
specializing in allogeneic hematopoietic cell transplantation (HCT) at IGEN/AFIP São Paulo and CHC/UFPR in Curitiba, Brazil
Moderated by: Bob McGonnagle, Publisher, CAP TODAY
Wednesday, June 24, 2026, 12:00–1:00 PM ET
Hear an expert discuss the expanded clinical utility of HER2 IHC scoring in metastatic breast cancer and its impact on your practice
Webinar presenter Michelle Shiller, DO, AP, CP, MGP, FACP, Baylor University Medical Center.
Moderated by: Bob McGonnagle, Publisher, CAP TODAY
Wednesday, July 15, 2026, 1:00-2:00 PM ET
Hear an expert discuss how to integrate Kappa and Lambda in situ hybridization testing into your standard hematopathology workflow to accurately assess B-cell and plasma cell clonality. You will also gain the skills to recognize testing pitfalls in challenging reactive versus neoplastic proliferations and apply ancillary tools to resolve complex cases.
Webinar presenter Xiaojun Wu, MD, PhD, Assistant professor, Director of Hematopathology Section at NCR of Johns Hopkins Medicine Department of Pathology, SOM at Johns Hopkins University
Moderated by: Bob McGonnagle, Publisher, CAP TODAY
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HORIBA Medical
| Company | HORIBA Medical |
|---|---|
| Name of instrument | Pentra C400 |
| City, State | Irvine, CA |
| Phone | 888-903-5001 |
| Website | |
| Type of instrument | chemistry |
| Operational type/Model type | batch, random access, continuous random access, discrete/benchtop |
| List price/First year sold in U.S. | $100, 000/2006 |
| Targeted hospital bed size/Targeted | ″ 250/daily: 1, 200; monthly: 24, 000; annual: 288, 000 |
| Company manufactures instrument | yes (also sold by distribution partners) |
| Other models in this family of analyzers | Pentra 400 |
| No. of units in clinical use in U.S./Outside U.S. (countries) | 650/ 1, 900 |
| Dimensions (H × W × D)/Instrument footprint | 25 × 40 × 28 in./7.7 sq. ft. |
| Weight empty/Weight fully loaded | 264 lbs./266 lbs. |
| No. of different measured assays onboard simultaneously | 55 (55 can be run and calibrated at one time) |
| No. of user-definable (open chemistry) channels | 40 (40 can be active simultaneously) |
| Test throughput per hour/Assay run time | 420 (4 tests in throughput)/1–10 min. (avg. 5 min.) |
| No. of direct ion-selective electrode channels | 3 |
| Detection methods | photometry, potentiometry, enzyme immunoassay immunoturbidimetry |
| • Ion-selective electrode | < 5 min./37 specimens per hr. |
| • Basic metabolic panel | 7.5 min./35 specimens per hr. |
| • Complete metabolic panel | < 11 min./23 specimens per hr. |
| Typical time delay from ordering stat test until aspiration of sample | < 1 min. |
| Fully automated microplate immunoassay system | — |
| Methodologies supported | — |
| Separation methodologies | — |
| Stat time until completion of a ß-hCG test | — |
| Stat time until completion of a cTn test | — |
| • Typical time delay from test order to aspiration of sample | — |
| Approximate No. of tests per reagent set/Reagent type | 100–400/self-contained multiuse, open reagent system |
| Reagents refrigerated onboard/Reagents ready to use | yes (2ϒ–8ϒC)/variable; reagent specific |
| Reagent lot tracking/Reagent inventory | yes/yes |
| Reagent form/Reagents barcoded | liquid chemistry (open reagent system)/yes |
| Separate reagent pack for each specimen/for each test run | no/no |
| Walkaway capability/Walkaway duration | yes/180 min. or 60 specimens or > 800 tests/assays |
| Design of sample-handling system | rack |
| Uses washable cuvettes/Uses disposable cuvettes | no/yes (can store up to 432 cuvettes) |
| Min.–max. sample volume that can be aspirated at one time | 2–60 µL |
| Min. reaction volume/Min. specimen volume/Min. dead volume | 180 µL/2 µL/100 µL |
| Dedicated pediatric sample cup | yes (dead volume: 100 µL) |
| Primary tube sampling | yes |
| Accommodates most standard tube sizes/Accepts nonstandard tube sizes | yes/yes |
| Pierces caps on primary tubes | no |
| Protects against probe collision | yes |
| Detects clots/liquid level/short sample | yes/yes/yes |
| Detection or quantitation for hemolysis, icterus, lipemia, clots | detection for clots; hemolysis, icterus, lipemia not available |
| Dilutes patient samples onboard/Susceptibility to carryover | yes (can be programmed to perform dilutions prior to analysis)/— |
| Automatic rerun capability | yes |
| Sample volume can be concentrated to rerun out-of-linear-range low results | yes |
| Analyzer requires dedicated water supply | no (average of 0.5 L/hr. consumption during operation) |
| Autocalibration/Multipoint calibration supported | yes (calibrants can be stored onboard)/yes (recommended avg. frequency: 14 days) |
| Typical calibration frequency for ISE/therapeutic drugs/drugs of abuse/general chemistries/immunoassays | 2 hrs. (automatic)/—/—/avg. 14 days/— |
| Automatic programmable start/Automatic programmable shutdown | yes (5 min. start-up time)/no |
| Onboard real-time QC/Onboard software capability to review QC | yes/yes |
| Supports multiple QC lot numbers per analyte | no |
| Waste management | direct to drain or container if no drain available |
| Sample barcode-reading capability/Autodiscrimination | yes (Interleaved 2 of 5, UPC, Codabar, Code 39, Code 128)/yes |
| Lab can control analyzer from remote computer | no |
| Instrument can diagnose its own malfunctions | yes (operator intervention required to order parts) |
| System malfunctions can be diagnosed via remote monitoring | yes |
| UPS backup power supply | no |
| Data-management capability/LIS or EHR systems interfaced | onboard/CGM LabDaq, Orchard, Cerner, Sunquest, Meditech, Schuyler House |
| LIS interface provided/Bidirectional interface capability | no/yes (broadcast download and host query) |
| Modem servicing provided/Service engineer on-site response time | no/< 24 hrs. |
| Mean time between failures | avg. 250 days (displays error codes for troubleshooting) |
| Average scheduled maintenance time by lab personnel | daily: < 5 min.; weekly: < 15 min.; monthly: < 30 min. |
| Maintenance records kept onboard for user/vendor | yes (includes audit trail of who replaced parts)/yes (includes audit trail of who replaced parts) |
| Maintenance training demonstration module onboard | no |
| Training included with purchase/Avg. time for basic user training | yes/2.5 days (at customer or vendor site) |
| Advanced operator training/Extra charge for follow-up or advanced training | yes (at vendor site)/yes |
| Warranty provided/Cost of annual service contract (24 h/7 d) | yes (1 year)/— |
| Distinguishing features (supplied by company) | full menu of moderately complex drugs of abuse and general chemistry assays; can run up to 55 assays onboard with 420 results/hr.; no requirement for external water system, no drain or special electrical required; remote diagnostics available for real-time troubleshooting; flexible, open-channel system capable of running ″ 40 third-party reagents onboard |