Anatomic pathology selected abstracts
July 2026—Hepatoid lung carcinomas, similar to hepatoid carcinomas of other sites, are defined as extrahepatic tumors exhibiting divergent hepatocellular differentiation. Uniquely, hepatoid carcinomas of the lung are reported to commonly express only HepPar1, which recognizes the mitochondrial enzyme carbamoyl-phosphate synthetase-1 (CPS1). HepPar1/CPS1 was recently found to accumulate in lung adenocarcinomas (LUAD) harboring STK11 mutations, presumably as a genotype-associated metabolic adaptation.