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Roundtable presenters John Longshore, PhD, Head of Scientific Affairs, Global Oncology Diagnostics, AstraZeneca, and Flora Berisha, MS, Executive Director, Global Head of Diagnostic Partnering and Development, Johnson & Johnson Innovative Medicine, and Mark D. Ewalt, MD, Associate Medical Director for Laboratory Operations, Diagnostic Molecular Pathology, Molecular Diagnostics Service, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, and Isabel Preeshagul, DO, MBS, Thoracic Medical Oncologist, Memorial Sloan Kettering Cancer Center

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This presentation will explore the value of in-house CGP, offer insights into the benefits and drawbacks of incorporation, and provide information about important practical factors when considering in-house implementation of CGP.

Webinar presenter Allison M. Cushman-Vokoun, MD, PhD, FCAP, Medical Director, Molecular Diagnostics and Personalized Medicine Laboratory, Director, Division of Diagnostic Molecular Pathology and Human Genetics, Henry F. Krous Professor of Pathology, University of Nebraska Medical Center

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Tuesday, October 20, 2026 11 AM-12 PM ET
Hear experts review the biological and clinical significance of the HER2 expression continuum in breast tissue, providing a clearer understanding of how these variations might impact diagnosis, and discuss the emerging importance of documenting HER2-low and HER2-ultralow categories using a validated IHC assay.

Webinar presenters Keith Wharton, MD, PhD, Global Medical Affairs Leader–Pathology, Roche Diagnostics Solutions, and Hannah Y. Wen, MD, PhD, Director, Breast Pathology Fellowship, Associate Team Leader, Breast Pathology Team, Attending Pathologist, Memorial Sloan Kettering Cancer Center

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Tuesday, November 3, 2026 1 PM-2 PM ET
Hear an expert discuss the challenges of detecting NRG1 fusions and how RNA-based testing can support more comprehensive fusion identification in clinical practice.

Webinar presenter Benjamin Weinberg, MD, Associate Professor of Medicine and Attending Physician
specializing in gastrointestinal medical oncology

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Moderated by: Bob McGonnagle, Publisher, CAP TODAY

Subspecialties

Interactive Product Guides

Product Spotlight

Beckman Coulter

DxC 500 AU Clinical Chemistry Analyzer

Company

Beckman Coulter

Name of instrument

DxC 500 AU Clinical Chemistry Analyzer

Contact

Doug Lee  

Email

dylee@beckman.com

City, State

Brea, CA

Phone

800-526-3821  

Website

https://www.beckmancoulter.com

Type of instrument

chemistry

Operational type/Model type

continuous random access/floor standing

List price/First year sold in U.S.

—/2024

Targeted hospital bed size/Targeted test volume

—/annual: 50,000–350,000

Company manufactures instrument

yes (also sold by distribution partners)

Other models in this family of analyzers

DxC 700 AU, AU5800

No. of units in clinical use in U.S./Outside U.S. (countries)

—

Dimensions (H × W × D)/Instrument footprint

48 × 61 × 31 in./52.1 sq. ft.

Weight empty/Weight fully loaded

—/maximum 992 lbs.

No. of different measured assays onboard simultaneously

63 (60 plus 3 ISE can be run and calibrated at one time)

No. of user-definable (open chemistry) channels

18

Test throughput per hour/Assay run time

up to 800: 400 photometric, 400 ISE/< 9 min.

No. of direct ion-selective electrode channels

3 indirect

Detection methods

photometry, potentiometry

Stat time until completion/specimen throughput for ion-selective electrode

—

Stat time until completion/specimen throughput for basic metabolic panel

—

Stat time until completion/specimen throughput for complete metabolic panel

—

Typical time delay from ordering stat test until aspiration of sample

—

Fully automated microplate immunoassay system

—

Methodologies supported

—

Separation methodologies

—

Stat time until completion of a ß-hCG test

—

Stat time until completion of a cTn test

—

• Typical time delay from test order to aspiration of sample

—

Approximate No. of tests per reagent set/Reagent type

—/self-contained single use

Reagents refrigerated onboard/Reagents ready to use

yes (4.5°–12°C)/variable; reagent specific

Reagent lot tracking/Reagent inventory

yes/no

Reagent form/Reagents barcoded

liquid chemistry (closed reagent system)/yes

Separate reagent pack for each specimen/for each test run

no/no

Walkaway capability/Walkaway duration

yes/168 specimens

Design of sample-handling system

rack

Uses washable cuvettes/Uses disposable cuvettes

yes (can store up to 88 cuvettes)/no

Min.–max. sample volume that can be aspirated at one time 

1–25 µL

Min. reaction volume/Min. specimen volume/Min. dead volume

90 µL/50 µL/80 µL

Dedicated pediatric sample cup

no

Primary tube sampling

yes

Accommodates most standard tube sizes/Accepts nonstandard tube sizes

yes/—

Pierces caps on primary tubes

no

Protects against probe collision

yes

Detects clots/liquid level/short sample

yes/yes/yes

Detection or quantitation for hemolysis, icterus, lipemia, clots

detection for hemolysis, icterus, lipemia, clots

Dilutes patient samples onboard/Susceptibility to carryover

yes (can be programmed to perform dilutions prior to analysis)/—

Automatic rerun capability

yes

Sample volume can be diluted to rerun out-of-linear-range high results

yes

Sample volume can be concentrated to rerun out-of-linear-range low results

yes

Autocalibration/Multipoint calibration supported

yes (calibrants are not stored onboard)/yes

Typical calibration frequency for ISE/therapeutic drugs/drugs of abuse/general chemistries/immunoassays

1 day/—/—/1–90 days/—

Automatic programmable start/Automatic programmable shutdown

yes/no

Onboard real-time QC/Onboard software capability to review QC

no/yes

Supports multiple QC lot numbers per analyte

—

Waste management

direct to drain

Sample barcode-reading capability/Autodiscrimination

yes (Interleaved 2 of 5, Code 39, Code 128, NW7, EAN-13, ISBT 128, Standard 2 of 5)/—

Lab can control analyzer from remote computer

yes

Instrument can diagnose its own malfunctions

yes (operator intervention required to order parts)

System malfunctions can be diagnosed via remote monitoring

yes

UPS backup power supply

yes

Data-management capability/LIS or EHR systems interfaced

onboard/Medicus, Evident, CGM LabDaq, Oracle Health, Clinisys

LIS interface provided/Bidirectional interface capability

no/yes (host query)

Modem servicing provided/Service engineer on-site response time

—

Mean time between failures

—

Average scheduled maintenance time by lab personnel

daily: 4 min.; weekly: 10 min.; monthly: 45 min.

Maintenance records kept onboard for user/vendor

yes/no

Maintenance training demonstration module onboard

yes

Training included with purchase/Avg. time for basic user training

yes (2 training slots)/—

Advanced operator training/Extra charge for follow-up or advanced training

yes (at vendor site)/—

Warranty provided/Cost of annual service contract (24 h/7 d)

—

Distinguishing features (supplied by company)

intuitive user interface with user-friendly software that guides workflow and anticipates laboratory needs; commonly replaced parts can be changed in 3 steps, in 60 seconds, and without tools; standardization across the AU family of chemistry analyzers

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