Clinical Pathology Selected Abstracts, 4/15
April 2015—Method precision and frequent causes of errors in point-of-care glucose testing; Safety considerations for testing specimens suspected or known to contain Ebola virus.
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Hear an expert discuss how Memorial Sloan Kettering Cancer Center (MSKCC) is utilizing
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This session is designed to improve understanding and application of recent updates to synoptic pathology reporting protocols such as the latest Reporting Template for Reporting Results of Biomarker Testing of Specimens from Patients with Carcinoma of the Breast. These changes reflect evolving clinical guidelines that directly influence diagnostic accuracy and treatment selection in breast cancer care.
Webinar presenters Thaer Khoury, MD, FCAP, Chair, Pathology and Laboratory Medicine, Roswell Park Comprehensive Cancer Cente, and Colin Murphy, CEO of mTuitive.
Moderated by: Bob McGonnagle, Publisher, CAP TODAY
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Abstracts
Anatomic Pathology Selected Abstracts, 3/15
March 2015—Histopathologic spectrum of thecoma of the ovary: a report of 70 cases: The authors evaluated 70 cases of thecoma of the ovary to ascertain their histopathologic spectrum. The tumors occurred over a wide age range (average, 49.6 years). Presentation in the form of pelvic or abdominal pain was uncommon, but postmenopausal bleeding was relatively frequent.
Clinical Pathology Selected Abstracts, 3/15
March 2015—Chimeric antigen receptor T cells for sustained remissions in leukemia: Relapsed and refractory acute lymphoblastic leukemia is associated with a poor prognosis. T cells genetically modified to express chimeric antigen receptors targeted to cells expressing CD19 (CTL019) are a promising treatment strategy, with complete responses previously reported in two patients who had relapsed and refractory acute lymphoblastic leukemia (ALL).
Molecular Pathology Selected Abstracts, 3/15
March 2015—Generation of allergen-specific human IgEs as standards in diagnostic allergy testing: Diagnostic allergy testing for patients with moderate to severe allergies is usually performed by an allergy specialist and can include skin prick and patch tests or blood tests.
Anatomic Pathology Selected Abstracts, 2/15
February 2015—Alteration of ARID1A gene, PI3K-Akt pathway, and ZNF217 gene in ovarian clear cell carcinoma: AT-rich interactive domain 1A (ARID1A) is a subunit of switch/sucrose nonfermentable (SWI/SNF) complex. Recently, alterations of the ARID1A gene, phosphatidylinositol 3-kinase-protein kinase B (PI3K-Akt) pathway, and zinc-finger protein 217 (ZNF217) gene have been identified as frequent molecular genetic changes in ovarian clear cell carcinoma.
Molecular Pathology Selected Abstracts, 2/15
February 2015—Exome and genome sequencing for neurodevelopmental disorders: Neurodevelopmental disorders, which affect more than three percent of children, are associated with a variable type and acuity of presentation, ranging from global developmental delay, to autism, to intellectual disability.
Clinical Pathology Selected Abstracts, 2/15
February 2015—Alcohol consumption relative to type of breast cancer risk in postmenopausal women: Alcohol consumption is a known risk factor for breast cancer, but it is not known which subtypes of breast cancer, if any, are more likely associated with alcohol consumption. The authors conducted a large study using the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial cohort to test for heterogeneity in alcohol-related risk by breast cancer subtypes defined by estrogen receptor (ER) and progesterone receptor (PR) status and histological type.
Clinical Pathology Selected Abstracts, 1/15
January 2015—Platelet transfusion: an AABB clinical practice guideline. Despite long-standing prophylactic use of platelet transfusions, an appropriate transfusion threshold has been a matter of debate. In particular, better data from newly emerging clinical studies has been a focus of this evolving debate.
Molecular Pathology Selected Abstracts, 1/15
January 2015—Age-related mutations linked to clonal hematopoietic expansion and malignancies: A common practice in molecular profiling of tumors is to subtract mutations detected in DNA derived from blood (representing germline or inherited polymorphisms) from mutations detected in DNA derived from the paired tumor to assess the tumor’s somatic molecular profile.
Anatomic Pathology Selected Abstracts, 1/15
January 2015—Are amended surgical pathology reports reaching the correct care provider? Amended reports need to follow patients to treating physicians to avoid erroneous management based on an original diagnosis. The authors undertook a study to determine if amended reports followed patients appropriately. They tracked amended reports with diagnostic changes and discrepancies between ordering and treating physicians.