Tuesday, October 20, 2026, 11 AM-12 PM ET
Hear experts review the biological and clinical significance of the HER2 expression continuum in breast tissue, providing a clearer understanding of how these variations might impact diagnosis, and discuss the emerging importance of documenting HER2-low and HER2-ultralow categories using a validated IHC assay.
Webinar presenters Keith Wharton, MD, PhD, Global Medical Affairs Leader–Pathology, Roche Diagnostics Solutions, and Hannah Y. Wen, MD, PhD, Director, Breast Pathology Fellowship, Associate Team Leader, Breast Pathology Team, Attending Pathologist, Memorial Sloan Kettering Cancer Center
CAP TODAY does not endorse any of the products or services named within. The webinar is made possible by a special educational grant from Roche.
Moderated by: Bob McGonnagle, Publisher, CAP TODAY
Thursday, October 29, 2026, 1 PM-2 PM ET
Hear an expert discuss the evolving role of PD-L1 testing in HNSCC and ovarian cancer.
Webinar presenter Georgios Deftereos, MD, Professor of Pathology, Associate Director of the Clinical Cancer Genomics Laboratory, Director of Molecular Cytopathology, University of California, San Francisco
CAP TODAY does not endorse any of the products or services named within. The webinar is made possible by a special educational grant from Agilent.
Moderated by: Bob McGonnagle, Publisher, CAP TODAY
Tuesday, November 3, 2026, 1 PM-2 PM ET
Hear an expert discuss the challenges of detecting NRG1 fusions and how RNA-based testing can support more comprehensive fusion identification in clinical practice.
Webinar presenter Benjamin Weinberg, MD, Associate Professor of Medicine and Attending Physician
specializing in gastrointestinal medical oncology
CAP TODAY does not endorse any of the products or services named within. The webinar is made possible by a special educational grant from Diaceutics.
Moderated by: Bob McGonnagle, Publisher, CAP TODAY
Monday, November 16, 2026, 12:30 PM-2 PM ET
Hear experts discuss a multidisciplinary approach to oncopathology for HER2
assessments for solid tumors in the absence of a companion diagnostic.
Webinar presenters Funda Meric-Bernstam, MD, Chair, Department of Investigational Cancer Therapeutics Medical Director, Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, and Emina E. Torlakovic, MD, PhD, College of Medicine, University of Saskatchewan, Canadian Biomarker Quality Assurance, Saskatoon, Saskatchewan, Canada, and Carol Cheung, MD, PhD, JD, FRCPC, Deputy Director, Canadian Biomarker Quality, Assurance—Programme canadien d’assurance de la qualité des biomarqueurs
CAP TODAY does not endorse any of the products or services named within. This program is being sponsored by Daiichi Sankyo, Inc. and AstraZeneca. The speaker is being compensated for the presentation. The program is not CME accredited and may not be used for CME accreditation.
Moderated by: Bob McGonnagle, Publisher, CAP TODAY
January 2026—The CAP released a guideline for amyloidosis lab workup, recommending Congo red staining for amyloid detection and mass spectrometry for fibril protein typing. The guideline emphasizes the importance of accurate and timely identification of amyloid fibril types for effective treatment.
December 2025—When this column comes out, it will be nearly the end of 2025. It’s a good time to think about the challenges we have been facing—and the opportunities we will have in the coming years to address them. The CAP is no stranger to challenges, and neither are its members. There’s a lot going on in the world and in the health care markets that directly affects what we do. I believe that if we face these challenges head-on, we can find ways to improve laboratory quality and our ability to care for patients, all while strengthening the CAP as an organization.
December 2025—The American Gastroenterological Association formalized, in 2020, iron-deficiency anemia recommendations for postmenopausal women and for men, which include esophagogastroduodenoscopy and colonoscopy, or bidirectional endoscopy. This guideline only conditionally recommended that bidirectional endoscopy be performed on premenopausal women, who are more likely to have iron-deficiency anemia (IDA) due to menorrhagia. The association also advised revising the World Health Organization’s recommended iron-deficiency diagnostic threshold of 15 ng/mL or lower ferritin to 45 ng/mL or lower. The authors used population-representative data from the National Health and Nutrition Examination Survey (NHANES) to assess the role of these recommendations in IDA prevalence estimates and management in the United States.
December 2025—Unusual morphologic patterns of breast carcinoma can raise diagnostic consideration for metastasis or special breast cancer subtypes and, thereby, impact clinical management and treatment. The authors conducted a study in which they described rare invasive breast cancers that mimic serous carcinoma of the gynecologic tract (serous-like breast carcinomas, SLBC) and characterized their clinicopathologic, immunophenotypic, and genetic features. The patients evaluated in the study were female (n = 15; median age, 49 years) and did not have a history of gynecologic malignancy. SLBC were characterized histologically by angulated, branched, sometimes anastomosing glands with micropapillary or pseudopapillary luminal projections in desmoplastic stroma. Most SLBC were triple negative (n = 10) or HER2 positive (n = 2) and grade 2 or 3, while some were estrogen receptor low positive/HER2 negative and low grade (n = 3). CK5/6 was positive irrespective of grade or receptor status (10 of 10).
December 2025—Two studies explore the evolution of Mycobacterium tuberculosis and the significance of GATA1 mutations in children with Down syndrome. The first study reveals diversity in virulence gene expression across Mtb clinical isolates, with variants in the regulator whiB6 linked to decreased expression of virulence factors and increased transmission of drug-resistant strains. The second study investigates the clinical significance of GATA1 mutations in neonates with Down syndrome, finding that the presence of GATA1s mutations at birth is a strong predictor of myeloid leukemia associated with Down syndrome (ML-DS).
December 2025—Mayo Clinic recently introduced Mayo Clinic Platform_Insights, an offering designed to advance the adoption of artificial intelligence by giving health care organizations around the world access to Mayo Clinic’s digital expertise, data-driven insights, and clinical knowledge. “When organizations partner with us, they gain access to proven clinical and administrative solutions and the technical framework to integrate them seamlessly,” according to a press statement from Maneesh Goyal, chief operating officer for Mayo Clinic Platform, an initiative that brings together health systems, innovators, and researchers to support responsible AI development worldwide.
December 2025
Q. Now that the CMS allows direct observation for competency assessment to be performed virtually, does the CAP also allow it? If so, can you provide guidance? Read answer.
Q. We have implemented quality control at 10x in accordance with the Westgard rules. I use three levels of QC. If the results of two levels of QC are moving properly above and below the mean and only one level is showing a trend of a 10x rule violation, what corrective action should I take? Read answer.
December 2025—A new Clinical and Laboratory Standards Institute document on external laboratory transport is expected to be released early next year. “It’s the first comprehensive framework for evaluating external specimen transport systems,” says Joe Wiencek, PhD, D(ABCC), document development chair and medical director and associate professor of pathology, microbiology, and immunology at Vanderbilt University Medical Center.
November 2025—Connecting with others is crucial for strengthening the pathology profession and improving patient care. This includes connecting with colleagues, patients, and other clinical partners to share ideas, resources, and expertise.
November 2025—Nicholas Barron, an osteopathic medical student, chose pathology after a personal health experience highlighted the field’s importance in diagnosis and healing. Izak B. Dimenstein supports the American Association of Pathologists’ Assistants’ definitions for pathologists’ assistants and grossing technicians, advocating for specialized training and certification programs to ensure quality assurance in surgical pathology.
