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This presentation will explore the value of in-house CGP, offer insights into the benefits and drawbacks of incorporation, and provide information about important practical factors when considering in-house implementation of CGP.

Webinar presenter Allison M. Cushman-Vokoun, MD, PhD, FCAP, Medical Director, Molecular Diagnostics and Personalized Medicine Laboratory, Director, Division of Diagnostic Molecular Pathology and Human Genetics, Henry F. Krous Professor of Pathology, University of Nebraska Medical Center

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Hear experts review the biological and clinical significance of the HER2 expression continuum in breast tissue, providing a clearer understanding of how these variations might impact diagnosis, and discuss the emerging importance of documenting HER2-low and HER2-ultralow categories using a validated IHC assay.

Webinar presenters Keith Wharton, MD, PhD, Global Medical Affairs Leader–Pathology, Roche Diagnostics Solutions, and Hannah Y. Wen, MD, PhD, Director, Breast Pathology Fellowship, Associate Team Leader, Breast Pathology Team, Attending Pathologist, Memorial Sloan Kettering Cancer Center

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Tuesday, November 3, 2026 1 PM-2 PM ET
Hear an expert discuss the challenges of detecting NRG1 fusions and how RNA-based testing can support more comprehensive fusion identification in clinical practice.

Webinar presenter Benjamin Weinberg, MD, Associate Professor of Medicine and Attending Physician
specializing in gastrointestinal medical oncology

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Moderated by: Bob McGonnagle, Publisher, CAP TODAY

Subspecialties

Interactive Product Guides

Product Spotlight

Sysmex Corp.

XN-330, XN-430, XN-530

Company

Sysmex Corp.

Name of analyzer

XN-330, XN-430, XN-530

Contact

Madelaine Dintelman  

Email

communications@sysmex.com

City, State

Lincolnshire, IL

Phone

888-879-7639

Website

https://www.sysmex.com

Analyzer application

diagnostic use

Dimensions of analyzer (H × W ×

XN-530: 17.7 × 17.7 × 26 in./varies by configuration

Country where analyzer was

Japan/Japan

First year analyzer was sold in U.S./Approximate No. of units installed in U.S.*

2017/>1, 500

First year analyzer sold outside

2015/—

Foreign locations where company

—

Human languages (other than

—

Analyzer list price

— (slide maker stainer sold separately)

• Analyzer acquisition options

purchase, trade in, lease, cost per reportable contract

Training included with purchase/Total time for basic training per operator

2 min. daily; 15 min. weekly

• Follow-up training available

yes (no extra charge)

Parameters that analyzer tests and reports

%&# eosinophils, %&# immature granulocytes, %&# lymphocytes, %&# monocytes, %&# neutrophils, %&# basophils, Hb, Hct, MCH, MCHC, MCV, PLT, RBC, WBC

Types of testing FDA cleared or approved for analyzer

blood count analysis, body fluid analysis

Types of body fluids FDA cleared or approved for analysis on analyzer

—

Analytical measurement range for body fluid

—

Precision for body fluid

—

Accuracy for body fluid

—

Automated differential performed for body fluids

—

Tests available for research use only

—

Differential methods used

fluorescent flow cytometry

Analytical measurement range: • WBC count/RBC count

WBC: 0.04–440.00 × 103/μL/RBC: 0.02–8.60 × 106/μL

Precision: • WBC count/RBC count

WBC: <3.0%/RBC: <1.5%

Accuracy: • WBC count/RBC count

—

Interfering substances: • WBC/RBC

no significant interference up to 39.4 mg/dL for bilirubin C, 37.4 mg/dL for bilirubin F, 996 mg/dL for hemolysis, 30.320 optical density for intralipid, 2, 880 OD for chyle/no significant interference up to 39.4 mg/dL for bilirubin C, 37.4 mg/dL for bilirubin F, 996 mg/dL for hemolysis, 30.320 optical density for intralipid, 2, 880 OD for chyle

• Hemoglobin/Platelets

no significant interference up to 39.4 mg/dL for bilirubin C, 37.4 mg/dL for bilirubin F, 199 mg/dL for hemolysis/no significant interference up to 39.4 mg/dL for bilirubin C, 37.4 mg/dL for bilirubin F, 996 mg/dL for hemolysis, 30.320 optical density for intralipid, 2, 880 OD for chyle

• Hematocrit/Reticulocytes

no significant interference up to 39.4 mg/dL for bilirubin C, 37.4 mg/dL for bilirubin F, 996 mg/dL for hemolysis, 30.320 optical density for intralipid, 2, 880 OD for chyle/—

• Automated differential

—

Throughput: max. CBCs per hour/Max. CBCs with differentials per hour

60/60

• Max. No. of slides processed per hour if stainer included

—

FDA-cleared or -approved sample container types (besides potassium EDTA)

none

Min. specimen volume open mode/Closed mode/Microsample capability

25 µL/25 µL/yes

Types of patient data archived/Max. No. of archived patient data accessible when analyzer online

demographics, results, flags/10, 000 results

Analyzer performs delta checks

yes

Parameters for which flags may appear

flags for all reportable parameters deemed abnormal per lab’s protocol, more

Analyzer recognizes and holds test results

yes, for potential test rerun

Scattergram display uses cell-specific color

yes

Histogram display uses color with thresholds

yes

LIS interface formats supported

ASTM 1381, ASTM 1394-97

• Middleware interface

yes (can use company’s middleware or Data Innovations)

• Information transferred to LIS via middleware or LIS interface

numeric results, flagged results, histograms, scatterplots, patient demographics, patient orders, host query for patient demographics and orders

Analyzer transmits LOINC codes for results to LIS or middleware

yes

Lab automation system or workcells to which analyzer has a direct interface

none

Barcode symbologies read on specimen tube

Codabar, Code 39, Code 128, ITF, NW-7, ISBT 128, JAN/EAN/UPC

• Analyzer allows barcode placement per CLSI standard Auto02-A2

yes

No. of onboard reagents required for standard specimen analysis

4

• Reagents ready to use/Reagent tracking method

yes/RFID, barcode reader

Onboard diagnostics for troubleshooting

yes

• Manufacturer can perform diagnostics via remote access

yes

Warranty provided/Cost of annual service contract (24 h/7 d)

one-year warranty/—

Notes

†also marketed by McKesson, Henry Schein

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in this guide

Alinity h-series
CELL-DYN Emerald†
CELL-DYN Emerald 22
CELL-DYN Emerald 22 Autoloader
GloCyte Automated Cell Counter for CSF
DxH 500 Hematology Analyzer
DxH 520 Hematology Analyzer
DxH 560 AL Hematology Analyzer
DxH 690T Hematology Analyzer
DxH 900 Workcell Automated Hematology Solution
ABX Micros 60
ABX Micros ES60
ABX Pentra 60C+
ABX Pentra XL80
Yumizen H2500
X100/X100HT with Full-Field Peripheral Blood Smear Application
XN-350, XN-450, XN-550
XN Series† (XN-1000, XN-2000, XN-3100, XN-9100)