December 2025—The American Gastroenterological Association formalized, in 2020, iron-deficiency anemia recommendations for postmenopausal women and for men, which include esophagogastroduodenoscopy and colonoscopy, or bidirectional endoscopy. This guideline only conditionally recommended that bidirectional endoscopy be performed on premenopausal women, who are more likely to have iron-deficiency anemia (IDA) due to menorrhagia. The association also advised revising the World Health Organization’s recommended iron-deficiency diagnostic threshold of 15 ng/mL or lower ferritin to 45 ng/mL or lower. The authors used population-representative data from the National Health and Nutrition Examination Survey (NHANES) to assess the role of these recommendations in IDA prevalence estimates and management in the United States.