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Webinars and Sponsored Roundtables — Register Now

Tuesday, October 20, 2026, 11 AM-12 PM ET
Hear experts review the biological and clinical significance of the HER2 expression continuum in breast tissue, providing a clearer understanding of how these variations might impact diagnosis, and discuss the emerging importance of documenting HER2-low and HER2-ultralow categories using a validated IHC assay.

Webinar presenters Keith Wharton, MD, PhD, Global Medical Affairs Leader–Pathology, Roche Diagnostics Solutions, and Hannah Y. Wen, MD, PhD, Director, Breast Pathology Fellowship, Associate Team Leader, Breast Pathology Team, Attending Pathologist, Memorial Sloan Kettering Cancer Center

CAP TODAY does not endorse any of the products or services named within. The webinar is made possible by a special educational grant from Roche.

Moderated by: Bob McGonnagle, Publisher, CAP TODAY

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Thursday, October 29, 2026, 1 PM-2 PM ET
Hear an expert discuss the evolving role of PD-L1 testing in HNSCC and ovarian cancer.

Webinar presenter Georgios Deftereos, MD, Professor of Pathology, Associate Director of the Clinical Cancer Genomics Laboratory, Director of Molecular Cytopathology, University of California, San Francisco

CAP TODAY does not endorse any of the products or services named within. The webinar is made possible by a special educational grant from Agilent.

Moderated by: Bob McGonnagle, Publisher, CAP TODAY

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Tuesday, November 3, 2026, 1 PM-2 PM ET
Hear an expert discuss the challenges of detecting NRG1 fusions and how RNA-based testing can support more comprehensive fusion identification in clinical practice.

Webinar presenter Benjamin Weinberg, MD, Associate Professor of Medicine and Attending Physician
specializing in gastrointestinal medical oncology

CAP TODAY does not endorse any of the products or services named within. The webinar is made possible by a special educational grant from Diaceutics.

Moderated by: Bob McGonnagle, Publisher, CAP TODAY

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Monday, November 16, 2026, 12:30 PM-2 PM ET
Hear experts discuss a multidisciplinary approach to oncopathology for HER2
assessments for solid tumors in the absence of a companion diagnostic.

Webinar presenters Funda Meric-Bernstam, MD, Chair, Department of Investigational Cancer Therapeutics Medical Director, Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, and Emina E. Torlakovic, MD, PhD, College of Medicine, University of Saskatchewan, Canadian Biomarker Quality Assurance, Saskatoon, Saskatchewan, Canada, and Carol Cheung, MD, PhD, JD, FRCPC, Deputy Director, Canadian Biomarker Quality, Assurance—Programme canadien d’assurance de la qualité des biomarqueurs

CAP TODAY does not endorse any of the products or services named within. This program is being sponsored by Daiichi Sankyo, Inc. and AstraZeneca. The speaker is being compensated for the presentation. The program is not CME accredited and may not be used for CME accreditation.

Moderated by: Bob McGonnagle, Publisher, CAP TODAY

Register Now

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Columns

Anatomic pathology selected abstracts

May 2025—Many pancreatic neuroendocrine tumors fall into two major prognostic subtypes based on DAXX/ATRX-induced alternative lengthening of the telomerase phenotype and alpha- and beta-cell-like epigenomic profiles. However, some do not fit into either subtype. Furthermore, despite advanced genotyping, pancreatic neuroendocrine tumors (PanNET) are generally not well characterized in terms of their histologic and hormonal phenotypes. The authors conducted a study to identify new subgroups of PanNET by extending transcription factor signatures and investigating their correlation with histologic, hormonal, molecular, and prognostic findings. One hundred eighty-five PanNET (165 nonfunctioning and 20 functioning), resected between 1996 and 2023, were classified into the subgroups A1, A2, B, C, and D.

Molecular pathology selected abstracts

May 2025—As genomic technology and scientific knowledge advance, so too do their applications in health care. Clinical genetic testing, preimplantation genetic diagnosis (PGD), and heritable human genome editing (HHGE) are an ever-growing and evolving part of genomic medicine. The author explored the significance of lived experiences with genetic disease relative to understanding the severity or seriousness of such diseases in the genomic age. She focused on severity of disease, perceptions of symptoms of disease or associations with disease, and interplay between symptoms of disease and associations with disease. The data presented were collected as part of a larger mixed-methods research project exploring factors that influence attitudes toward the use of HHGE as a potential reproductive choice in the United Kingdom and how identifying those factors could aid the design of future regulations.

Q&A column

May 2025
Q. Our laboratory is considering adding whole slide imaging to our surgical pathology case workflow. The quality of the slides can have a negative impact on the scanning of the histologic sections. How can our histology laboratory produce histologic preparations that are optimal for whole slide imaging scanning? Read answer.

Q. Are there biological reference intervals for spot urine values for creatinine, protein, microalbumin, sodium, potassium, and calcium? Some reagent manufacturers give reference intervals for spot urine tests. Is this necessary? Read answer.

Newsbytes

May 2025—Duke University has launched its Duke Center for Computational and Digital Health Innovation, which is intended to drive technological advances in the areas of wearable sensors, high-performance computing, and extended reality solutions. “Our center provides a vibrant platform for innovation and collaboration, where researchers, clinicians, engineers, and industry partners work side-by-side to pioneer new solutions,” says an open letter from Amanda Randles, PhD, director of the center. Faculty support for the center comes from the Duke University School of Medicine, School of Nursing, Trinity College of Arts and Sciences, and Pratt School of Engineering.

Put It on the Board

May 2025—Ninety-nine percent of laboratory professionals say medical couriers impact their work in a “typical week,” with 81 percent of respondents who work in acute care labs indicating the impact is “significant,” according to a CAP TODAY survey sponsored by MedSpeed. Of the 318 laboratory professionals who responded to the 2025 CAP TODAY survey, 84 percent said that in the last month a medical courier delay or error impacted their ability to provide appropriate and timely results for patients, with an average of three such incidents reported per month per respondent. Fifty-six percent of laboratory directors, managers, and supervisors indicated that a courier error compromised an irreplaceable specimen in the last year, with an average of two such incidents reported per respondent per year. And 83 percent of laboratory directors, managers, and supervisors said courier reliability affects their decision to partner with specialty labs or complementary labs for send-out and referral testing.

 

From the President’s Desk

April 2025—If you read my monthly column often, you probably know that leadership among pathologists is one of my favorite topics. And one of the most important leadership roles we play as pathologists is as leaders of the laboratory diagnostic team. Our years of training prepare us to view a patient’s health holistically and to interpret test results in the context of the patient’s full clinical picture.

Clinical pathology selected abstracts

April 2025—Regulatory requirements in title 45, section 164.524 of the Code of Federal Regulations state that covered entities must provide patients or their designated representatives with patient health care records upon request. This is true for all laboratory testing, including such complex texting as next-generation sequencing (NGS). The protected health information that can be requested includes billing and payment records and clinic notes. Exceptions to the requirement to provide protected health information are very limited. However, questions arise with regard to complex laboratory testing, such as what information related to genomic testing should be included in the data set and what should be taken into consideration for the release and receipt of this information.

Anatomic pathology selected abstracts

April 2025—Claudin-18.2 (CLDN18.2) is a biomarker for locally advanced or metastatic gastric and gastroesophageal junction adenocarcinomas that may respond to targeted therapy with monoclonal antibodies directed against CLDN18.2. Despite successful testing in clinical trials, no practical testing guidelines had been proposed at the time the authors’ article featured herein was published. Several preanalytical and analytical variables may interfere with CLDN18.2 staining interpretation. Therefore, the authors provided practical guidance on CLDN18.2 testing and scoring in gastric and gastroesophageal junction adenocarcinomas. They established criteria pertaining to sample characteristics, analytical requirements, staining evaluation, and reporting.

Pathology informatics selected abstracts

April 2025—Hirschsprung disease is characterized by the absence of ganglion cells in the intestinal wall. Determining whether ganglion cells are present in an effort to identify Hirschsprung disease is a cumbersome task for pathologists that may require frozen section analysis; histopathologic assessment of a rectal biopsy specimen (the gold standard); use of special stains, such as AChE; IHC analysis of calretinin or S100; or molecular and genetic testing. To assist pathologists with evaluating challenging frozen sections, the authors developed an artificial intelligence (AI) solution designed to enhance the detection of ganglion cells during intraoperative consultation. The AI model was trained using a mixed data set that combined 366 frozen section and 302 formalin-fixed, paraffin-embedded H&E-stained slides procured from 164 patients across three medical centers in Turkey. After scanning the slides, pathologists helped train the deep learning model by annotating ganglion cells present in the whole slide images (WSI).

Molecular pathology selected abstracts

April 2025—Chronic kidney disease is more common in people of African ancestry, with Americans of African descent having four times the risk compared with Americans of European descent. This disparity is largely due to the G1 and G2 genetic variants in the APOL1 gene, which increase the risk of developing chronic kidney disease (CKD) when inherited in a homozygous or compound heterozygous pattern. These variants, exclusive to African populations, likely evolved over 10,000 years ago due to their protective role against African sleeping sickness. The prevalence of these variants varies across sub-Saharan Africa, and data on their connection to CKD in African populations are limited.

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