Room to grow: tumor-germline sequencing
February 2025—Genetic profiling has long had proven winners in oncology: somatic testing of tumors, and germline testing for surveillance and to identify potentially affected relatives.
Webinars and Sponsored Roundtables — Register Now
Wednesday, September 23, 2026. 12 PM-1 PM ET
Roundtable presenters Dr. David Sacks MB, ChB, FRCPath, Chairman, Steering Committee National Glycohemoglobin Standardization Program (NGSP), and Priya Sivaraman, PhD, Senior Technical Product Manager, Tosoh Bioscience.
Moderated by: Bob McGonnagle, Publisher, CAP TODAY
Thursday, September 24, 2026 11 AM-12 PM CT
This session explores the evolving role of RAS in precision oncology, from the biology of RAS mutations to the expanding landscape of targeted therapies. Through expert presentations, real-world case discussions, and interactive audience polling, participants will examine best practices for RAS biomarker testing across solid tumors, including lung, colorectal, and pancreatic cancers. The session will highlight practical considerations for tissue and liquid biopsy, strategies to address testing gaps, and the importance of multidisciplinary collaboration to ensure timely identification of patients who may benefit from RAS-targeted therapies.
Webinar presenters David Braxton, MD, Chief of Molecular Pathology Services, Hoag Family Cancer Institute & Hoag Memorial Hospital Presbyterian, and Carlos Becerra, MD, Research Director for Medical Oncology, Margaret Given Larkin Endowed Chair for Developmental Cancer Therapeutics, Hoag Memorial Hospital Presbyterian.
Moderated by: Bob McGonnagle, Publisher, CAP TODAY
Wednesday, September 30, 2026. 1 PM-1:30 PM ET
Roundtable presenters John Longshore, PhD, Head of Scientific Affairs, Global Oncology Diagnostics, AstraZeneca, and Flora Berisha, MS, Executive Director, Global Head of Diagnostic Partnering and Development, Johnson & Johnson Innovative Medicine, and Mark D. Ewalt, MD, Associate Medical Director for Laboratory Operations, Diagnostic Molecular Pathology, Molecular Diagnostics Service, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, and Isabel Preeshagul, DO, MBS, Thoracic Medical Oncologist, Memorial Sloan Kettering Cancer Center.
Moderated by: Bob McGonnagle, Publisher, CAP TODAY
Tuesday, October 20, 2026 11 AM-12 PM ET
Hear experts review the biological and clinical significance of the HER2 expression continuum in breast tissue, providing a clearer understanding of how these variations might impact diagnosis, and discuss the emerging importance of documenting HER2-low and HER2-ultralow categories using a validated IHC assay.
Webinar presenters Keith Wharton, MD, PhD, Global Medical Affairs Leader–Pathology,
Roche Diagnostics Solutions, and Hannah Y. Wen, MD, PhD, Director, Breast Pathology Fellowship, Associate Team Leader, Breast Pathology Team, Attending Pathologist, Memorial Sloan Kettering Cancer Center.
Moderated by: Bob McGonnagle, Publisher, CAP TODAY
Subspecialties
Interactive Product Guides
February 2025
The shift from cotesting to primary HPV screening
February 2025—Eric Huang, MD, PhD, is the first to admit that when it came time to switch to primary HPV testing, his laboratory at the University of Washington faced fewer obstacles than most. Dr. Huang joined the university in 2018 as director of the cytopathology laboratory.
In chemistry and more, what to know about new checklist edition
February 2025—In the 2024 accreditation program checklist edition, released Dec. 26, are new and revised requirements for chemistry, diagnostic immunology, and flow cytometry laboratories. Two of the flow cytometry requirements are now also in the anatomic pathology checklist.
USCAP meeting presenters take us inside for early look
February 2025—HER2 in predictive biomarker testing, HPV-related cancer testing guidelines, and the art of applying polygenic risk scores will be some of what’s heard in USCAP 2025 sessions next month in Boston.
AMP case report: A 67-year-old female with rare intracranial mesenchymal tumor featuring the EWSR1::CREM fusion gene
February 2025—Intracranial mesenchymal tumors (IMT) are extremely rare and account for only 0.3 percent of soft tissue tumors. Most frequently, mesenchymal tumors occur in subcutaneous tissue; they are rarely described in the central nervous system. In addition, these tumors typically occur in young adults,1 with a median patient age of 14 (range: four to 70).
Requirement changes in microbiology, transfusion checklists
February 2025—Some of the CAP accreditation program requirements in the 2024 microbiology and transfusion medicine checklists, in the edition released Dec. 26, have been revised to simplify, clarify, and conserve resources. In transfusion, one new requirement was added to define policy requirements for the use of low-titer group O whole blood.
Views on digital pathology, AI, and the AP LIS
February 2025—Digital pathology, artificial intelligence, and anatomic pathology computer systems—seven participants in a Dec. 10, 2024 online roundtable talked with CAP TODAY publisher Bob McGonnagle about their experiences, plans, and predictions. Large academic center practices and small pathology practices—they considered all perspectives. Here is what they told us.
From the President’s Desk
February 2025—Five years ago, many of us were grappling with the earliest cases of a novel coronavirus in the United States. During the COVID-19 pandemic that ensued, we pathologists became more visible in a variety of ways, both to our clinical colleagues and to the general public.
Anatomic pathology selected abstracts
February 2025—Pulmonary complications cause significant morbidity and mortality in post-hematopoietic stem cell transplantation. The histopathology of pulmonary diseases in the context of post-hematopoietic stem cell transplantation (post-HSCT) is poorly characterized, especially in the pediatric population. The authors sought to characterize the pathologic spectrum of pulmonary disease post-HSCT in a pediatric cohort. Fifty-six specimens, including 53 biopsy specimens, corresponding to 53 patients were identified. Biopsy slides were reviewed and assigned to diagnostic categories (infectious, graft-versus-host disease, vasculopathy, indeterminate, and others) by consensus among three pediatric pulmonary pathologists, taking into consideration pathologic, clinical, radiologic, and laboratory findings.
Clinical pathology selected abstracts
February 2025—Low titer group O whole blood is commonly used for severe bleeding in trauma patients. It may also benefit pediatric patients undergoing cardiopulmonary bypass who are at risk for massive bleeding and coagulopathies. Circuit anticoagulation, hypothermia, hemodilution, coagulation factor, platelet loss and dysfunction, an underdeveloped hemostasis system in patients younger than two years old, and other factors lead to a higher risk of bleeding. Compared with component therapy, whole blood contains higher concentrations of RBCs, platelets, and coagulation factors, as well as cold platelets with enhanced hemostatic function. Due to the logistical challenges of donor centers providing ABO-specific whole blood for cardiopulmonary bypass (CPB), the use of longer storage-age low titer group O whole blood (LTOWB) may be an option for younger pediatric patients with severe bleeding on CPB.