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Launch Digital Edition

Webinars and Sponsored Roundtables — Register Now

Tuesday, June 9, 2026, 1:00–2:00 PM ET
In this webinar, we will examine how immune recognition after allogeneic HCT can influence leukemia relapse and disease progression. The session will highlight the clinical relevance of HLA loss of heterozygosity (LOH), approaches used for its detection, and how LOH findings may support transplant strategies, including considerations for donor selection in subsequent transplantation.

Webinar presenter Alberto Cardoso Martins Lima, PhD, Clinical consulting scientist in histocompatibility,
specializing in allogeneic hematopoietic cell transplantation (HCT) at IGEN/AFIP São Paulo and CHC/UFPR in Curitiba, Brazil

Moderated by: Bob McGonnagle, Publisher, CAP TODAY

Register Now

Wednesday, June 24, 2026, 12:00–1:00 PM ET
Hear an expert discuss the expanded clinical utility of HER2 IHC scoring in metastatic breast cancer and its impact on your practice

Webinar presenter Michelle Shiller, DO, AP, CP, MGP, FACP, Baylor University Medical Center.

Moderated by: Bob McGonnagle, Publisher, CAP TODAY

Register Now

Wednesday, July 15, 2026, 1:00-2:00 PM ET
Hear an expert discuss how to integrate Kappa and Lambda in situ hybridization testing into your standard hematopathology workflow to accurately assess B-cell and plasma cell clonality. You will also gain the skills to recognize testing pitfalls in challenging reactive versus neoplastic proliferations and apply ancillary tools to resolve complex cases.

Webinar presenter Xiaojun Wu, MD, PhD, Assistant professor, Director of Hematopathology Section at NCR of Johns Hopkins Medicine Department of Pathology, SOM at Johns Hopkins University

Moderated by: Bob McGonnagle, Publisher, CAP TODAY

Register Now

Subspecialties

Interactive Product Guides

Subspecialties

Can AML become the new CML? How NCI trial works

December 2024—A National Cancer Institute trial known as MyeloMATCH, rolling out now, aims to improve the acute myeloid leukemia survival rate and relies on 72-hour turnaround times for cytogenetics, FISH, flow cytometry, and next-generation sequencing. In MyeloMATCH (Molecular Analysis for Therapy Choice), researchers are hoping to find new treatments for AML and myelodysplastic syndrome by rapidly matching patients with a trial that tests a treatment designed to target the mutations detected in the patient blood and bone marrow samples.

Outlook on outreach—who’s doing what?

December 2024—Some health systems have sold their clinical laboratory outreach business; others seek to grow theirs. CAP TODAY publisher Bob McGonnagle asked Compass Group members for a quick look at their outreach programs when they met online on Nov. 5. The Compass Group is an organization of not-for-profit IDN system laboratory leaders who collaborate to identify and share best practices and strategies.

Evaluation of the genetic findings in B-cell lymphoma in the context of clinicopathological data

December 2024—Case. A 73-year-old male with a clinical history of benign prostatic hypertrophy and pituitary macro­adenoma status post-resection presented with lymphocytosis. This incidental lymphocytosis was noted within a preoperative CBC for a prostate procedure. At the time he was asymptomatic; medications included hydrocortisone, testosterone, and levothyroxine. Lymphadenopathy and splenomegaly were absent on physical examination. Complete blood counts showed WBC 25.8 × 109/L, hemoglobin 13.9 g/dL, hematocrit 42 percent, and platelets 134 × 109/L.

Rethinking maternal AFP race adjustments

November 2024—David Grenache, PhD, D(ABCC), chief scientific officer of TriCore, is breaking no new ground when he considers the maternal serum alpha-fetoprotein test and says, “A screening test is designed to put people into one of two camps.” No scientific advances there. But the reverberations of this particular screening test have landed patients and physicians in complicated situations of late. The obvious divide is to identify increased risk of fetal abnormalities, including open neural tube defects. But the test has historically incorporated a race adjustment for Black patients. And that adjustment—seen as a way to account for reported differences in AFP values between Black and non-Black pregnant persons—in turn has come under more scrutiny recently as physicians question whether the adjustment should continue to be used, or whether it should be dropped, à la the race adjustment for eGFR/renal function. Compared with eGFR, evaluating the race adjustment in maternal serum AFP screening is more in its infancy, Dr. Grenache says.

Respiratory virus readiness, H5N1 ramp-up

November 2024—When it comes to what diseases are predicted to circulate and when, expect a respiratory virus season much like last year’s, and the year before that. As for the severity? “That’s anybody’s guess,” says Alesia McKeown, PhD, scientific partner, medical and scientific affairs at Roche Diagnostics, speaking in late September.

With eGFR in EHR, stronger clinical decision support

November 2024—In health care, information overload is hardly a novel problem. But when it comes to overlooking impaired kidney function in the electronic health record, Children’s Mercy Kansas City found a novel fix—at least for a pediatric institution. The solution, says Darcy Weidemann, MD, MHS, pediatric nephrologist at Children’s Mercy Kansas City and associate professor, University of Missouri-Kansas City School of Medicine, was to implement estimated glomerular filtration rate in the EHR.

Inside new edition of gyn cytopathology guide

November 2024—New this month from CAP Publications is the CAP Practical Guide to Gynecologic Cytopathology—Morphology, Management, and Molecular Methods, second edition. Its 15 chapters cover squamous and glandular epithelial abnormalities, anal cytology, benign changes and mimics of premalignant and malignant epithelial lesions, and much more. In this issue we provide part of the chapter on look-alikes and morphologic spectrums of change.

AMP case report: Molecular insights into the bi-clonal presence of inversion 16 and Philadelphia chromosome in relapsed post-treatment acute myeloid leukemia

November 2024—Acute myeloid leukemia (AML) stands out as the most prevalent form of leukemia, constituting 80 percent of cases in adults and 15 to 20 percent in children. It arises from the clonal proliferation of genetically aberrant hematopoietic stem and progenitor cells, impeding normal hematopoiesis. AML is linked to a variable number of cytogenetic abnormalities, and the identification of these abnormalities holds crucial implications, given their association with an elevated risk of inherited AML.

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