New accreditation POC requirements for coagulation testing
January 2025—The point-of-care checklist in the 2024 accreditation checklist edition, released Dec. 26, now includes requirements on coagulation specimen collection and handling.
Webinars and Sponsored Roundtables — Register Now
Thursday, August 20, 2026. 12 PM-1:30 PM ET
Hear from an expert in HER2 IHC whose work has contributed to current scoring guidelines.
Webinar presenter Josef Ruschoff, MD, PhD, Former Chief Medical Officer and Co-Founder of Targos, Senior Consultant of Discovery Life Sciences, Kassel, Germany.
Moderated by: Bob McGonnagle, Publisher, CAP TODAY
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Learn about digital pathology technology that is future-ready, yet practical for today’s
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Webinar presenters Scott Hammond, Senior Systems Consultant, Digital Pathology Division, Wexner Medical Center, Department of Pathology, and Ursula Hofer, Imaging Technologist, Pathology Digital Imaging Lab, Wexner Medical Center, Department of Pathology, and Sandra Banky, PA(ASCP), Director of Operations, Wexner Medical Center, Department of Pathology.
Moderated by: Bob McGonnagle, Publisher, CAP TODAY
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Subspecialties
DPYD genotyping assays—what’s recommended and why
January 2025—A study published last year found variability in the variants tested for in the commercial lab DPYD genotyping assays available at the time of the study, underscoring “the importance of comprehensive DPYD genotyping to accurately identify patients with DPD deficiency,” the authors said. Compromised dihydropyrimidine dehydrogenase deficiency raises a cancer patient’s risk of fluorouracil toxicity.
Should grade group 1 prostate cancer be renamed?
January 2025—Whether grade group 1 prostate cancer should be renamed to “noncancer” was the center of debate on a CAP podcast last fall led by Gladell P. Paner, MD, in discussion with Ming Zhou, MD, PhD, and Rajal B. Shah, MD. Dr. Paner is professor of pathology and surgery, University of Chicago Pritzker School of Medicine, and director of the genitourinary pathology service and of the reproductive endocrinology and infertility laboratory, UChicago Medicine.
Critical result notifications at the point of care
January 2025—A clinical laboratory team at Ohio State University Wexner Medical Center took on a point-of-care testing problem common to other hospitals: documentation of critical result notification. At OSU, the documentation rate for point-of-care glucose critical result notification wasn’t high enough, and the team set out to raise it. It’s not sufficient to notify the physician or other provider. “You then have to prove you’re doing this, with documentation that the notification did in fact exist,” said Heather Stieglitz, PhD, D(ABCC), OSU co-director of clinical chemistry and toxicology, in an ADLM point-of-care testing session last summer.
Pearls and pitfalls in renal mass biopsy
January 2025—Renal mass biopsy has become an indispensable pre-management diagnostic tool, especially as incidental renal masses are increasingly detected with modern imaging techniques. It offers the patient the opportunity to get a definitive diagnosis without necessitating nephrectomy, especially helpful for patients with advanced disease or those who are poor surgical candidates. This is crucial, as certain renal cell carcinoma (RCC) subtypes have significantly different prognostic outcomes and therapeutic implications, making it essential to subtype RCCs in addition to distinguishing between benign and malignant lesions. For instance, systemic treatment strategies diverge markedly between clear cell RCC and non-clear cell RCC subtypes, underscoring our role in guiding personalized therapy choices. This article synthesizes key findings and diagnostic challenges most encountered on renal mass biopsy, with a focus on clear cell RCC, clear cell papillary renal cell tumor, TFE3-rearranged RCC, papillary RCC, oncocytoma, and chromophobe RCC.
A win for all: clinical affiliation with cytology training programs
January 2025—It is well documented that the cytologist/cytotechnologist workforce is diminishing and the number of training programs has declined. According to the Centers for Medicare and Medicaid Services, CT participation in gynecologic proficiency testing has decreased by 27 percent since 2005. New board certifications of CTs or specialists in CT(SCT) decreased by about 56 percent over the same period. CT(ASCP) and all SCT(ASCP) certifications are now recognized by the CMS and the Centers for Disease Control and Prevention per 42 CFR §493.1483.
Beyond the microscope: expanding the role of cytopathologists
January 2025—The traditional image of a pathologist is often that of a scientist working in a laboratory, handling chemical solutions, or peering through a microscope. Over the past decade, pathologists, including those specializing in cytopathology, have increasingly moved beyond those confines, taking on more prominent roles in patient-facing care. This article explores the various ways cytopathologists are expanding their roles, engaging directly with patients and physicians and positioning themselves at the forefront of the management team.
Coagulation automation, from workflow to middleware
Automation in coagulation was the topic of a Nov. 11, 2024 roundtable led by CAP TODAY publisher Bob McGonnagle. Put it on a line or on a dedicated automation platform? Seven participants talked about that and about cybersecurity, viscoelastic testing, and the labor shortage, among other things.
CAR T-cell therapy moves into the fast lane
December 2024—There is no disguising the enthusiasm—not to mention expertise—that David Miklos, MD, PhD, brings to the topic of chimeric antigen receptor T-cell therapies. CAR T-cell products have been strikingly effective in treating large B-cell lymphoma and multiple myeloma, as well as other hematologic malignancies such as acute lymphoblastic leukemia, follicular lymphoma, and mantle cell lymphoma. Sounding equal parts life coach and physician, Dr. Miklos sees nearly limitless potential in this immunotherapy, which entails genetically engineering T cells to express engineered molecules that can recognize and bind to specific antigens on cancer cells. “So much is possible,” he says. “Our little minds are limiting this, not the potential of science. There are a lot of obvious and mind-blowingly effective strategies that are just coming home to roost. We have really blown open the opportunity to advance therapies more quickly, to apply multipronged approaches using logic loops that are essentially programmed into a cell. It’s really exciting.”
Time for wider pretreatment DPYD genotyping?
December 2024—On the heels of the publication of a joint consensus recommendation on DPYD genotyping, setting out what variants to test for, two experts who have studied the use of DPYD genotyping shed light in CAP TODAY interviews on its importance and its real-world impact.