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AMP case report: Follicular lymphoma of gallbladder, November 2017

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Dr. Shi is a pathology resident, Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada. Dr. Alomari is a pathologist, Department of Pathology and Laboratory Medicine, Windsor Regional Hospital, Windsor, Ontario, Canada. Dr. Yang is an assistant professor and cytogeneticist/molecular geneticist, Dr. Sadikovic is an associate professor and molecular geneticist/cytogeneticist, Dr. Sangle is an assistant professor and pathologist, and Dr. Howlett is an assistant professor and pathologist—all in the Department of Pathology and Laboratory Medicine at Western University and London Health Sciences Centre, London, Ontario, Canada.

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Test yourself

Here are three questions taken from the case report.
Answers are online now at www.amp.org/casereports and will be published next month in
CAP TODAY.

1. Which of the following is true with regard to follicular lymphoma involving the gallbladder and biliary system?

a) Patient always presents with constitutional symptoms.

b) Patient often presents with symptoms of biliary colic.

c) bstructive jaundice is common.

d) The gallbladder is a common site for primary follicular lymphoma.

e) Patients are primarily in their 30s and 40s.

2. What proportion of follicular lymphomas harbor an IGH/BCL2 translocation?

a) Approximately 40 percent

b) Approximately 10 percent

c) Approximately 85 percent

d) 100 percent

3. Which of the following is true regarding PCR-based assays for clonality using Biomed-2 primer sets?

a) The IGH assay alone has low sensitivity.

b) For germinal center and post-germinal center lymphomas, sensitivity is improved by combining IGH and IGK assays.

c) Somatic hypermutation has no effect on primer annealing.

d) Follicular lymphoma has a lower rate of somatic hypermutation than other lymphomas.
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