AMP case report: Identification by NGS of a diagnostic and theranostic mutation in a high-grade sarcoma of the humerus

Create PDF

2. What molecule is isocitrate converted to by IDH1/2 enzymes?

a. D-2-hydroxyglutarate
b. 2-oxyglutarate, also known as α-ketoglutarate
c. Isocitrate
d. Citrate
e. Succinyl Co-A

3. What is the key oncometabolite produced as a result of gain of function of IDH2 due to mutations in the Arg140 or Arg172 residues?
a. D-2-hydroxyglutarate
b. 2-oxyglutarate, also known as α-ketoglutarate
c. Isocitrate
d. Citrate
e. Succinyl Co-A

Test yourself answers for December 2018 case report

In the December 2018 issue was a case report, “Discordant IHC/PCR test results for mismatch repair status in colorectal adenocarcinoma,” written by members of the AMP. Here are answers to the three “test yourself ” questions that followed that case report.

1. A recent report by Bartley, et al. (Cancer Prev Res [Phila]. 2012; 5[2]:320–327) estimates the rate of discordance between IHC and PCR-based assays for mismatch repair at approximately:

a. 0.1 percent
b. 2 percent
c. 10 percent
d. 20 percent
e. 55 percent

2. Why is it important to test for mismatch repair/microsatellite instability status of colorectal cancers?

a. It provides key information about tumor staging.
b. Patients with intact MMR have a better overall prognosis.
c. Patients with intact MMR should have routine extra-colonic cancer screenings.
d. It provides potential risk information for patients’ family members.

3. Which of the following is the correct interpretation of a tumor’s mismatch repair status with intact MMR protein expression by IHC but MSI-high by PCR?
a. Intact
b. Deficient
c. Indeterminate