Big interest, gaps in early pancancer testing
August 2025—There’s the cart before the horse. There are certain equines that should not be flogged; others should not be backed. There’s closing the stable door at an unfortunate time.
Webinars and Sponsored Roundtables — Register Now
Thursday, May 28, 2026, 1:00–2:00 PM ET
This session is designed to improve understanding and application of recent updates to synoptic pathology reporting protocols such as the latest Reporting Template for Reporting Results of Biomarker Testing of Specimens from Patients with Carcinoma of the Breast. These changes reflect evolving clinical guidelines that directly influence diagnostic accuracy and treatment selection in breast cancer care.
Webinar presenters Thaer Khoury, MD, FCAP, Chair, Pathology and Laboratory Medicine, Roswell Park Comprehensive Cancer Cente, and Colin Murphy, CEO of mTuitive.
Moderated by: Bob McGonnagle, Publisher, CAP TODAY
Tuesday, June 9, 2026, 1:00–2:00 PM ET
In this webinar, we will examine how immune recognition after allogeneic HCT can influence leukemia relapse and disease progression. The session will highlight the clinical relevance of HLA loss of heterozygosity (LOH), approaches used for its detection, and how LOH findings may support transplant strategies, including considerations for donor selection in subsequent transplantation.
Webinar presenter Alberto Cardoso Martins Lima, PhD, Clinical consulting scientist in histocompatibility,
specializing in allogeneic hematopoietic cell transplantation (HCT) at IGEN/AFIP São Paulo and CHC/UFPR in Curitiba, Brazil
Moderated by: Bob McGonnagle, Publisher, CAP TODAY
Wednesday, June 24, 2026, 12:00–1:00 PM ET
Hear an expert discuss the expanded clinical utility of HER2 IHC scoring in metastatic breast cancer and its impact on your practice
Webinar presenter Michelle Shiller, DO, AP, CP, MGP, FACP, Baylor University Medical Center.
Moderated by: Bob McGonnagle, Publisher, CAP TODAY
Subspecialties
Interactive Product Guides
Subspecialties
The fine points of NIFTP interpretation
August 2025—The noninvasive follicular thyroid neoplasm with papillary-like nuclear features, or NIFTP, is an entity that was introduced nearly a decade ago. It’s a lesion no longer considered malignant and instead grouped with more indolent lesions, owing to its observed indolent clinical behavior.
Study reveals extrachromosomal DNA’s impact
August 2025—Detection of extrachromosomal DNA in a tumor was found in a study published late last year to be associated with tumor stage, more prevalent after targeted and cytotoxic therapy, and associated with metastases and shorter overall survival.
Capillary and venous blood equivalence studied for routine tests
August 2025—For routine diagnostic testing, capillary blood is a reliable alternative to venous blood, say the authors of a study published in May. The study was led by Babson Diagnostics, of Austin, Tex., an independent startup spun out of Siemens Healthineers. Babson says it’s the first to validate capillary blood as a viable option for routine testing.
D-dimer reporting, INR among the variables that matter
August 2025—Anticoagulant interference, INR calculation, and D-dimer reporting are among the coagulation testing analytical and postanalytical variables that merit caution. Andrew Goodwin, MD, and Eric Salazar, MD, PhD, in a CAP24 session dug into why and what the requirements are, including for viscoelastic testing.
A blood management road map in WHO’s latest guidance
August 2025—The World Health Organization released new guidance this spring to provide aid in implementing patient blood management programs and toolkits to support blood health and patient safety at various resource levels. “It’s the job of the clinician to make the right decisions about blood use at the right time. Patient blood management programs help them do that,” says Sherri Ozawa, MSN, RN, a coauthor of the WHO guidance. “What documents like this and others do is help make the bridge between what laboratory professionals already know and changing clinical practice.” Ozawa is director of patient blood management operations for hc1 of Indianapolis, Ind., a company that optimizes laboratory data to improve clinical practice, enabling better patient care, streamlining operations, and reducing costs.
The quest to detect hemolysis in POC blood gas testing
August 2025—Werfen launched in July 2024 its Gem Premier 7000 with iQM3 blood gas testing system. One year in, CAP TODAY publisher Bob McGonnagle spoke with Werfen’s Kristina Powell, Ken Huffenus, and Sofia Afonso for the latest on that and about what Werfen showcased at the ADLM meeting last month.
Cytopathology in focus: Navigating papillary lesions in Lynch syndrome
August 2025—Case summary. A 52-year-old chronic smoker with a known MLH1 mutation and Lynch syndrome presented with a pleural-based lung lesion. Fine-needle aspiration revealed a malignant neoplasm with papillary architecture, featuring enlarged overlapping nuclei, coarse chromatin, prominent nucleoli, and rare mitotic figures. Given the patient’s clinical background and cytologic findings, a broad differential diagnosis including primary and metastatic tumors from both thoracic and ab-dominal origins was considered.
Cytopathology in focus: Small samples, big impact: cytology specimens in the molecular era
August 2025—Strides in medical imaging techniques and procurement methods have led to the acquisition of small diagnostic samples obtained by minimally invasive techniques. Over the same period, the breadth of molecular information that can be derived from limited tumor material has increased exponentially. In the age of targeted cancer therapy, the clinical utility of this information is substantial and, when coupled with the decreasing costs of molecular analysis, the information transformed the treatment landscape of cancer. These advances have brought cytology back into the spotlight as a potential source of material for biomarker analysis.
Cytopathology in focus: What’s new in ’25 head and neck SCC guideline?
August 2025—Human papillomavirus testing has become the standard of care in head and neck squamous cell carcinoma (HNSCC) because of the unique clinical features, staging, and treatment options for HPV-associated HNSCC. HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) exhibits a favorable prognosis and improved response to chemoradiation compared with conventional HNSCC and non-HPV-associated forms, and reporting the HPV status is frequently part of clinical trial enrollments. Many patients with OPSCC present with enlarged level II or III cervical lymph nodes and, as a result, cervical lymph node fine-needle aspiration is often the first, and sometimes only, tissue obtained for diagnostic testing. With a growing menu of options available to test for HPV status, including polymerase chain reaction, DNA in situ hybridization, mRNA ISH, liquid-based HPV assays, and p16 immunohistochemistry, it is not always clear when and which HPV test to use, especially when the diagnosis is made on a cytology specimen.