CAP TODAY Pathology/Laboratory Medicine/Laboratory Management
Approval is based on results from the phase three IMpower133 study, which showed that Tecentriq in combination with chemotherapy helped people live significantly longer compared with chemotherapy alone (median overall survival=12.3 versus 10.3 months; hazard ratio=0.70, 95 percent CI: 0.54–0.91; p=0.0069) in the intention-to-treat population. The Tecentriq-based combination also significantly reduced the risk of disease worsening or death compared with chemotherapy alone (PFS=5.2 versus 4.3 months; HR=0.77; 95 percent CI: 0.62–0.96; p=0.017).
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