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Cytopathology and More | Negative Pap, positive hrHPV: what we know so far

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  1. Saslow D, Solomon D, Lawson HW, et al. American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. Am J Clin Pathol. 2012;137:516–542.
  2. Hariri S, Unger ER, Sternberg M, et al. Prevalence of genital human papillomavirus among females in the United States, the National Health and Nutrition Examination Survey, 2003–2006. J Infect Dis. 2011;204:566–573.
  3. Katki HA, Schiffman M, Castle PE, et al. Five-year risks of CIN3+ and cervical cancer among women with HPV testing of ASC-US Pap results. J Low Genit Tract Dis. 2013;17:S36–S42.
  4. Bruni L, Diaz M, Castellsagué X, Ferrer E, Bosch FX, de Sanjosé S. Cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings. J Infect Dis. 2010;202:1789–1799.
  5. Khan MJ, Castle PE, Lorincz AT, et al. The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice. J Natl Cancer Inst. 2005;97:1072–1079.
  6. Bansal M, Austin RM, Zhao C. High-risk HPV DNA detected in less than 2% of over 25,000 cytology negative imaged liquid-based Pap test samples from women 30 and older. Gynecol Oncol. 2009;115:257–261.
  7. Wright TC Jr, Stoler MH, Sharma A, et al.; ATHENA Study Group. Evaluation of HPV-16 and HPV-18 genotyping for the triage of women with high-risk HPV+ cytology-negative results. Am J Clin Pathol. 2011;136:578–586.
  8. Zhao C, Chen X, Onisko A, Kanbour A, Austin RM. Follow-up outcomes for a large cohort of US women with negative imaged liquid-based cytology findings and positive high risk human papillomavirus test results. Gynecol Oncol. 2011;122:291–296.
  9. Schiffman M, Burk RD, Boyle S, et al. A study of genotyping for management of human papillomavirus-positive, cytology-negative cervical screening results. J Clin Microbiol. 2015;53:52–59.
  10. Woodard A, Austin RM, Li Z, Beere J, Zhao C. Prevalence of HPV 16/18 genotypes and histopathologic follow-up outcomes in women with negative cytology and positive high-risk HPV test results. J Am Soc Cytopathol. Epub ahead of print March 6, 2015. dx.doi.org/10.1016/j.jasc.2015.03.001.
  11. Khanna A, Patel S, Gong Y, Staerkel G, Guo M. The efficacy of HPV 16/18 genotyping in predicting CIN2+ in women with HPV+/Pap- results. J Am Soc Cytopathol. 2014;3:S1–S2 (abstract PP03).
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Dr. Ocque is a cytopathology fellow and Dr. Zhao is a professor of pathology and associate director of cytopathology, Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center. Dr. Zhao is a member of the CAP Cytopathology Committee.

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