Pressure’s on to halt nosocomial infections

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Dr. Massie

“These findings are particularly important when you consider the time it takes for hospitals to put patients into contact isolation. The 90th percentile for turnaround times was on the order of almost three days, which means the patients weren’t in isolation for a significant period of time,” Dr. Massie notes.

Institutions that rely on culture methods to detect MRSA are not only at the mercy of bacterial growth rates, but can also find it difficult to keep up with a large volume of samples. Molecular tools can help hospital laboratories overcome these hurdles, but the biggest drawback is cost.

“Molecular methods can be expensive,” Dr. Massie acknowledges, but “institutions should consider, based upon their prevalence of MRSA, whether the cost of non-culture methods would be offset by fewer hospital-acquired infections.”

Detection of C. difficile is a different story: Nearly two-thirds of the participating labs already use molecular tools to detect the organism’s toxigenic phenotype. Far fewer labs use ELISA, a method found to be much less sensitive than nucleic acid amplification. “Hospitals or laboratories that are using those methods should consider whether they’re still being effective,” Dr. Massie says.

A number of labs now use a screening algorithm that begins with a test for a C. difficile antigen and confirms the result using a molecular probe. “As C. difficile has become more frequent, there has been a migration to nucleic acid amplification as a more automated, sensitive confirmatory test,” Dr. Meier says. “There’s a shift away from attempting to detect toxins by just an antigen test, or more rarely by a cell culture technique that detects the toxigenic effect on cells.”

The bottom line, the authors report, is that labs using nucleic acid amplification to detect nosocomial pathogens around the clock will sort patients significantly faster than other labs.

The Q-Probes study produced other interesting results. While the average surveillance detection rate for MRSA was about 11.4 percent, consistent with other published studies, the authors were surprised to find a dramatic variation in MRSA prevalence among the participating hospitals.

“One thing I found particularly intriguing was the incredible range—from roughly five percent to 55 percent—between laboratories, in terms of their isolation of MRSA from surveillance tests,” Dr. Massie says. “Usually studies will report just the average surveillance rate. So when we looked at individual institutions, that broad range really surprised me.”

The authors found that MRSA is more often detected during surveillance than by clinical testing, with a mere 2.4 percent clinical detection rate. By contrast, C. difficile had similar rates of surveillance and clinical detection of 5.7 percent and 4.9 percent, respectively.

Though the reasons for these disparities are not entirely clear, the authors speculate that hospitals with higher MRSA prevalence likely admit more patients from nursing homes or long-term care facilities. Regardless of the underlying reason, the finding is significant because hospitals can face entirely different challenges depending on the prevalence of MRSA.

“It’s important to know how many patients will be presenting with these infections so you can plan what you’re going to do. If you have a lot of these patients, isolation can become impractical depending on how large and complex your organization is,” says Dr. Meier. “That said, the direct laboratory cost of MRSA screening for patients from chronic care facilities seems to be valuable. You pick up MRSA more efficiently if you screen all of those patients.”

Equally important is remembering, the authors warn, that just because one area of the hospital has a low prevalence of MRSA doesn’t mean other areas are necessarily safe. “It might be useful to look at specific units, such as ICUs, where there’s a higher risk of hospital-acquired infections due to more central lines and other invasive procedures,” Dr. Massie says, “especially if hospitals don’t want the expense of doing all of the surveillance.”

The Q-Probes findings have a number of potential implications for clinical practice, the authors note.

“There still is controversy in the literature as to the best approach for handling hospital-acquired infections due to MRSA. Some early studies suggested there was no benefit to doing surveillance cultures and putting patients with MRSA into contact isolation,” Dr. Massie says. “But in a lot of those studies, there were breakdowns in the hospitals’ contact precautions, meaning they weren’t fully implemented. If you’re only adhering to contact isolation part of the time, you’re not really achieving your end goals.”

In 2007, a Veterans Health Administration directive implemented a “MRSA bundle,” which mandated universal nasal surveillance screening for MRSA on all patients admitted to ICU or non-ICU settings, and required VA hospitals to use contact precautions, including hand hygiene, when interacting with patients found to be colonized or infected with MRSA.

“At my institution, we had to adopt universal screening but we chose to go with a molecular method, rather than trying to culture the organism because that simply takes too long. And then, of course, we put people into contact isolation if they are found to be positive,” Dr. Massie says. Though the VHA directive does not require decolonization of patients with MRSA, Dr. Massie’s hospital opts to decolonize patients or initiate an eradication protocol consisting of intranasal Mupirocin, as well as chlorhexidine baths and mouthwash.
A few years after the mandate was in place, the VA reported a systemwide decrease in MRSA transmission and infections (Jain R, et al. N Engl J Med. 2011;364:1419–1430).

A more recent report in the New England Journal of Medicine supports the practice of universal decolonization, finding that it may be more effective than either targeted decolonization or screening and isolation at reducing rates of MRSA clinical isolates (Huang SS, et al. N Engl J Med. 2013:368:2255–2265).
But Dr. Massie isn’t so sure. “Decolonizing everybody puts a lot of pressure on the organisms to develop resistance,” he says. “These organisms have a tremendous capacity to adapt. It wouldn’t surprise me if we start to see more resistance with the overuse of these decolonization protocols.”

On a more encouraging note, Dr. Massie says, about 22 percent of the participating laboratories offered a fecal transplant program for patients with recurrent C. difficile infections. “That almost a quarter of the labs in our study have those programs in place really highlights the difficulty that health care is facing with regard to this particular disease,” Dr. Massie says. “Once patients relapse, they’re more likely to relapse again. At some point, there just isn’t much therapy available, and that’s when these fecal transplants can be very effective.”

The Q-Probes study also identified a few opportunities to conserve cost and effort. “Roughly a quarter of labs had no limits on the number of samples that could be submitted,” Dr. Massie says. “Other labs were performing C. difficile testing on formed stool, which typically is not as valuable because one to three percent of individuals normally carry C. difficile. If they’re not having diarrhea, it really isn’t a problem.”

Like the recent CDC report, the Q-Probes study looked of different types of hospitals to better understand surveillance and detection of the two most common nosocomial pathogens. “About a third of the participating hospitals were really small, a third were medium-sized, and a third were really big,” Dr. Meier says. “We’ve represented urban, suburban, and rural settings. So it’s a small study but a fairly representative one.”
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Ann Griswold is a writer in San Francisco.