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1. Comper WD, Osicka TM, Jerums G. High prevalence of immuno-unreactive intact albumin in urine of diabetic patients. Am J Kidney Dis. 2003;41[2]:336–342.
2. Osicka TM, Comper WD. Characterization of immunochemically nonreactive urinary albumin. Clin Chem. 2004;50[12]:2286–2291.
3. Sviridov D, Meilinger B, Drake SK, Hoehn GT, Hortin GL. Coelution of other proteins with albumin during size-exclusion HPLC: implications for analysis of urinary albumin. Clin Chem. 2006;52[3]:389–397.
4. Peters T Jr. How should we measure the albumin in urine [editorial]? Clin Chem. 2006;52[4]:555–556.
5. Miller WG, Bruns DE, Hortin GL, et al.; National Kidney Disease Education Program–IFCC Working Group on Standardization of Albumin in Urine. Current issues in measurement and reporting of urinary albumin excretion. Clin Chem. 2009;55[1]:24–38.
6. Speeckaert MM, Speeckaert R, Van De Voorde L, Delanghe JR. Immunochemically unreactive albumin in urine: fiction or reality? Crit Rev Clin Lab Sci. 2011;48[2]:87–96.
7. Bachmann LM, Nilsson G, Bruns DE, et al. State of the art for measurement of urine albumin: comparison of routine measurement procedures to isotope dilution tandem mass spectrometry. Clin Chem. 2014;60[3]:471–480.

John H. Eckfeldt, MD, PhD, Ellis Benson Professor, Department of Laboratory, Medicine and Pathology, University of Minnesota Medical School Minneapolis

Member, CAP Chemistry, Resource Committee Member, CAP Accuracy Based Testing Committee
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Dr. Kiechle is a consultant, clinical pathology, Cooper City, Fla. Use the reader service card to submit your inquiries, or address them to Sherrie Rice, CAP TODAY, 325 Wau­ke­gan Road, Northfield, IL 60093; srice@cap.org. Those questions that are of general interest will be answered.