CAP TODAY Pathology/Laboratory Medicine/Laboratory Management
The S protein of SARS-CoV-2 is located on the surface of the viral particles and comprises two functional units, S1 and S2. The N-terminal S1 subunit is responsible for virus-receptor binding and the C-terminal S2 subunit mediates virus–cell membrane fusion. When used solely or in combination with the company’s insect-derived nucleocapsid protein (N), the S1-S2 chimeric glycoprotein has demonstrated excellent reactivity in ELISA for detection of IgA, IgG, and IgM antibodies against SARS-CoV-2.
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