AMP case report: Role of lymphoma sequencing panel in diagnosis of pediatric-type follicular lymphoma

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Conclusion. The absence of BCL2 and BCL6 rearrangements and variants in epigenetic modifiers, the identification of MAP2K1 and TNFRSF14 mutations, and the clinical presentation (young male with cervical lymphadenopathy) all contributed in this case to the refinement of the initial diagnosis of typical follicular lymphoma to PTFL. This report emphasizes the importance of gene sequencing studies in the diagnostic workup of clinically challenging lymphoma cases.

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Dr. Yang was a hematopathology fellow (at the time the case report was written), Dr. Caponetti is assistant professor of clinical pathology and laboratory medicine, Dr. Roth is assistant professor of clinical pathology and laboratory medicine, Dr. Elenitoba-Johnson is the Peter C. Nowell, MD, professor and director of the Center for Personalized Diagnostics and of the Division of Precision and Computational Diagnostics, and Dr. Lim is professor of pathology and laboratory medicine and director of hematopathology—all at the University of Pennsylvania Perelman School of Medicine and the Hospital of the University of Pennsylvania. Dr. Yang is now an instructor, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School.

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