AMP case report: CCND1/IGH fusion amplification in a case of plasma cell myeloma

1. Which of the following is true about the t(11;14)(q13;q32) translocation?
a. It is found exclusively in plasma cell myeloma.
b. It results in a fusion gene with oncogenic potential.
c. It places the CCND3 gene downstream of the IGH promoter.
d. It leads to constitutive expression of cyclin D1.

2. Which cellular function is primarily disrupted by the t(11;14)(q13;q32) trans­location?
a. Energy metabolism
b. Cell cycle regulation
c. Telomere maintenance
d. Regulation of angiogenesis

3. Using a dual-color/dual-fusion probe set that hybridizes to CCND1 and IGH, a typical t(11;14)(q13;q32) translocation would give the following hybridization pattern:
a. Two fusion signals, one red signal, and one green signal
b. Two fusion signals
c. Two red signals and two green signals
d. Six or more fusion signals

1. Which of the following is true about the t(11;14)(q13;q32) translocation?
a. It is found exclusively in plasma cell myeloma.
b. It results in a fusion gene with oncogenic potential.
c. It places the CCND3 gene downstream of the IGH promoter.
d. It leads to constitutive expression of cyclin D1.

2. Which cellular function is primarily disrupted by the t(11;14)(q13;q32) trans­location?
a. Energy metabolism
b. Cell cycle regulation
c. Telomere maintenance
d. Regulation of angiogenesis

3. Using a dual-color/dual-fusion probe set that hybridizes to CCND1 and IGH, a typical t(11;14)(q13;q32) translocation would give the following hybridization pattern:
a. Two fusion signals, one red signal, and one green signal
b. Two fusion signals
c. Two red signals and two green signals
d. Six or more fusion signals