With molecular MPN testing, think positive

For myeloproliferative neoplasms, morphologic and clinical findings should guide molecular analysis, which can often be a helpful way to clinch the diagnosis, says Dr. David Czuchlewski (left), of TriCore Reference Laboratories, with Mohammad Vasef, MD, TriCore’s director of molecular diagnostics.

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Dr. David Czuchlewski (left)
and Mohammad Vasef, MD

Genetic profiling vies with IHC in
retune of CUP testing

Tesla beats Camry. Online catalogs replace paper. Keurig edges out Chemex. Mobile trounces landline. When paradigms shift, the theory goes, we can only cling to the technology in the outbox for just so long. But that’s a theory that may not apply to diagnostic testing for cancer of unknown primary (CUP).

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Charles R. Handorf, MD, PhD

Groups closing the gap in reference materials for sequencing assays

It’s a truism in the clinical laboratory that your results are only as good as the reference standards available to QC your assay. For measuring small analytes like glucose that’s not a problem. However, in clinical laboratories the analyte in question increasingly is DNA. In the past five years, next-generation sequencing has been adopted to detect variants in small targeted regions of specific genes, which is useful in oncology and medical genetics.

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Deanna Church, PhD

Hear me now? Another audition
for speech recognition

Switching from transcription to speech recognition is “one of the best decisions we ever made in my practice here,” says Dr. Fisher, medical director of the Kalispell Regional Medical Center laboratory near Montana’s Glacier National Park. He is part of an independent pathology group that provides services to the hospital.

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Dr. Anil Parwani (left)
with Juliet Filter, PA(ASCP)

March 2015 Issue

With molecular MPN testing, think positive | Genetic profiling vies with IHC in retune of CUP testing | Reference materials for sequencing assays

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Submissions Now Accepted for
CAP ’15 Abstract Program

Abstract and case study submissions are now being accepted for the College of American Pathologists (CAP) 2015 meeting, which will be held October 4th through the 7th in Nashville, Tennessee. Submissions will be accepted from: February 9, 2015 through April 10, 2015.

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ATHENA trial—an interview with Thomas Lorey, MD

The Food and Drug Administration on April 24 approved use of the Roche Cobas HPV test as a primary standalone screen for cervical cancer in women 25 and older. For a discussion of the ATHENA data on which the FDA based its decision, see Dr. Check’s June story “Data spark new directions in cervical cancer.”

Archives: HPV primary screening for cervial cancer—an interview with Ritu Nayar, MD.

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Consensus offered on IPMNs

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EHRs fall short in displaying Dx results

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When to replace your LIS

Jan. 29, 2015—Laboratory informatics plays a vital role in helping labs expand their reach and become more involved in patient outcomes. The latest Orchard Software white paper reviews how to evaluate whether a laboratory information system can help carry out that task, and when it is time to look for something new. Read it.
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AFB PCR’s utility; evaluating large B-cell lymphomas

Two articles have been released early online this month by The Archives of Pathology & Laboratory Medicine. One study (abstract | PDF) concludes that traditional diagnostics such as histopathology, acid-fast bacilli smear, and culture should continue to take precedence over AFB PCR in detecting mycobacteria in clinical specimens.
   The other early release (abstract | PDF) reviews the different immunohistochemical features used for identification, subclassification, prognosis, and sometimes treatment of diffuse large B-cell lymphoma and related lymphomas, based on 2014 literature and the authors’ experience with routine cases.

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