When to fire up large multiplex PCR?

Multiplex PCR panels are used first-line at Loyola, and an evaluation of outcomes is ongoing. “We’re going to be looking at everything we possibly can, and we’ll report it,” says Paul Schreckenberger, PhD, director of the clinical microbiology laboratory at Loyola University Medical Center.

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Dr. Paul Schreckenberger

Rebooting IHC for companion diagnostics

Given the number of proteins that are targets for immunotherapy and other targeted therapies, immunohistochemistry should theoretically be the ideal method for classifying patients as responders versus non-responders. But there are several reasons why IHC hasn’t reached this status within personalized medicine, says Clive R. Taylor, MD, DPhil, professor of pathology in the Keck School of Medicine of the University of Southern California.

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Dr. Clive R. Taylor

In next-gen sequencing,
panel versus exome

In genetic testing for Mendelian disorders, it is not a question of panels or exomes. Rather, the challenge is how to combine the two to support the most useful services, says Heidi L. Rehm, PhD, an associate professor of pathology at Brigham and Women’s Hospital and Harvard Medical School.

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Dr. Heidi L. Rehm

Cases focus on ALK false-negs,
post-transplant tumor

Damon Olson, MD, a fourth-year pathology resident at the University of Colorado, Denver, related a “Tale of Two ALK False-Negative Lung Adenocarcinomas” at a session at the Association for Molecular Pathology annual meeting. One was falsely negative by FISH and the other by immunohistochemistry, both FDA-approved methods.

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Dr. Damon Olson

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January 2016 Issue Articles

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» When to fire up large multiplex PCR?
» Rebooting IHC for companion diagnostics
» In next-gen sequencing, panel versus exome
» Cases focus on ALK false-negs, post-transplant tumor
» From the President’s Desk: Flexibility matters
» All January 2016 articles

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